Lecture - Prof Stephen Durham - "Allergen immunotherapy: a model of human antigen-specific tolerance"

27/04/2017 11:00 to 27/04/2017 14:00

Lycée Technique d'Esch/Alzette
Esch/Alzette, Luxembourg

Speaker

Prof Stephen DURHAM is Head of Section for Allergy and Clinical
Immunology at NHLI, Imperial College and Professor of Allergy and Respiratory Medicine at Royal Brompton Hospital, London, United Kingdom

ABSTRACT

Allergen immunotherapy is highly effective in patients with severe seasonal
hayfever. Both subcutaneous and sublingual routes of administration are effective when given for 3 years and have been shown to induce long-term tolerance for at least several years thereafter. The mechanism of immunotherapy has been shown to involve suppression of local tissue eosinophilia and decreases in the IgE-dependent activation of mast cells and basophils through the induction of ‘protective’ long-lived memory T cell and B cell responses. In a recent single centre Immune Tolerance Network
NIAID-funded double-blind placebo-controlled clinical trial (n=106), we showed that whereas 2 years grass pollen SLIT and SCIT were highly effective, 2 years was insufficient for long-term tolerance. There were coordinated effects observed on all 3 arms of the immune response with suppression of local and systemic effector cells, a decrease in antigen-
specific Class II tetramer-positive T cells and increases in ‘functional’ IgG blocking antibody responses that paralleled the clinical response to treatment. (Scadding G et al., JAMA 2017;317;615-25).

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SCHEDULE

11:00 - 12:00 : LECTURE

Lycée Technique d'Esch/Alzette - Salle de projection audiovisuelle

12:30 - 14:00 : 'meet & eat'

House of BioHealth
Room Françoise Barré-Sinoussi

Registration required for the 'Meet & Eat' - send us an email.

About the Lecture & Workshop series - Infection & Immunity

The LIH Lecture Series and Workshops in Infection and Immunity, supported by the FNR, are gathering internationally recognised speakers to address topics around Infection and Immunity. Twelve lectures will be organised in 2017, followed by workshops especially dedicated to early-stage researchers. Please find here the full programme for 2017.

Attendance to the lectures and workshops are free of charge. Should you be interested in registering for the workshops, please feel free to do so by sending us an email.

Where

Lycée Technique d'Esch/Alzette
32 rue Henri Koch
    Esch/Alzette 4354
    Luxembourg

When

From 27/04/2017 11:00
To 27/04/2017 14:00

Contact

Luxembourg Institute of Health
odoo@lih.lu