CANCELLED | How metabolism influences cancer progression » Luxembourg Institute of Health
Home » Events » CANCELLED | How metabolism influences cancer progression

CANCELLED | How metabolism influences cancer progression

01/12/2022 11:00 to 13:30
  • Lecture Series Cancer Research

Please note that this event has been cancelled. We will update you with any future reschedule date.


Prof Matthew
Vander Heiden

Koch Institute for Integrative Cancer Research at MIT


Complex regulatory mechanisms enable cell metabolism to match physiological state. How specific cancers use metabolism to support proliferation is determined both by cell intrinsic factors (such as tissue of origin and driver mutations) and the nutrients available to cells within the tumor. Accumulating evidence suggests that nutrient availability in tissues is heavily influenced by tissue site and non-cancer cells in the tissue, such that tissue location is a major determinant of nutrient availability leading to each tissue having a unique nutrient environment.

This has implications for understanding how cancer cells use nutrients to support proliferation and survival, and might limit both sites of metastasis and response to cancer therapy. Specifically, we find that to metastasize, cancer cells have to adapt to the nutrient conditions found within a particular organ, and that nutrient conditions can also impact gene expression in cells. These topics, and their implications for cancer biology will be discussed.

Responsible Scientist

Supported by:



Read more about the “Data Protection Notice: processing of personal data in the scope of events’ management”.

Forthcoming events