Translational Medicine Operations Hub (TMOH)
TMOH offers the infrastructure to support translational medicine research.
activities
The Translational Medicine Operations Hub (TMOH) ensures full research support from the operational planning of the study to their execution and closure via the collection, processing, storage and analysis of high-quality biological samples and structured clinical data.
The Translational Medicine Operations Hub (TMOH) includes the operational units of the LIH (CPMO, CIEC, CCMS, IBBL) and its collaborative platforms (LCTR, DMSP, LuxGen, RPP) to integrate and optimise their accessibility, workflows and project/portfolio oversight.
The TMOH provides the infrastructure to intra-institutional research, as well as transversal translational projects of “Research Luxembourg” and collaborations with external partners. These include publicly funded Research Projects like LITMUS, NCER-PD and CLINNOVA, as well as collaborations with industry partners. The central contact point of TMOH is the CPMO, which will guide researchers and their projects through the TMOH processes, as well as plan and track project execution.
As part of its mission, the TMOH hopes to improve patients’ lives by providing Operational Excellence:
- Single Point of contact regarding Research Services for internal & external stakeholders
- Seamless workflow and high-quality project execution
- Consultation for projects regarding project design, operations, regulatory aspects, among others
- Inbuilt collaboration (clear processes, interfaces, R&R) and exchange of resources (technologies, SME)
- Transparent information/communication E2E (TMOH, LIH and beyond…)
- Continuous development – of methods, technology, science, quality, and processes, among others
Director of department
The Department was established in July 2021, and Dr Hermann Thien was appointed as its Director. Hermann gained over 20 years of experience in the Pharmaceutical and Diagnostics Industry before joining LIH in March 2021.
Thien
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Clinical Project Management Office (CPMO)The CPMO coordinates the planning of the operational aspects of translational research…
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Clinical and Epidemiological Investigation Center (CIEC)The CIEC supports research and health care institutions, international academia and pharmaceutical industry players, providing them with high quality clinical research and services.
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Luxembourg Clinical and Translational Research Centre (LCTR)As a collaboration between the Centre Hospitalier de Luxembourg (CHL) and LIH,…
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National Cytometry PlatformThe NCP provides the best technology coupled with a thoughtful experimental design…
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Competence Centre for Methodology and StatisticsThe Competence Center for Methodology and Statistics (CCMS) aims to support LIH…
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Disease Modeling & Screening Platform (DMSP)The disease modelling and screening platform (DMSP) is a core facility that…
Projects & clinical trials
Featured team members
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Francisco Javier
Alves Ferreira Visiting Researcher -
Wim
Ammerlaan Head of Biorefinery -
Valéry
Bocquet Biostatistician -
Dominique
Brault eClinical Project Manager -
Dmitry
Bulaev Data Analyst -
Aljosa
Celebic Data Manager -
Olfa
Chouchane-Mlik Visiting Researcher -
Adrian
Cuevas Bourdier Visiting Researcher
Scientific publications
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Publisher Correction – 02/09/2022
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Age at onset as stratifier in idiopathic Parkinson’s disease – effect of ageing and polygenic risk score on clinical phenotypes – 09/08/2022
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The gut microbial metabolite formate exacerbates colorectal cancer progression – 01/01/2022
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Results from EDIFICE : A French pilot study on COVID-19 and the gut microbiome in a hospital environment – 08/02/2022
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Fitness for purpose of stabilized stool samples for bile acid metabolite analyses – 12/04/2021
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Fibroblast mitochondria in idiopathic Parkinson’s disease display morphological changes and enhanced resistance to depolarization – 01/12/2020
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Method Validation for Extraction of DNA from Human Stool Samples for Downstream Microbiome Analysis – 01/04/2020
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Effect of Different Proteinase K Digest Protocols and Deparaffinization Methods on Yield and Integrity of DNA Extracted From Formalin-fixed, Paraffin-embedded Tissue – 01/03/2020
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Standardization of the preanalytical phase of DNA extraction from fixed tissue for next-generation sequencing analyses – 25/01/2020
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Blood DNA Yield but Not Integrity or Methylation Is Impacted after Long-Term Storage – 01/01/2016
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