Immune Endocrine and Epigenetics

The Immune Endocrine and Epigenetics focuses on the molecular mechanisms underlying the environmental control of phenotype development. 


Stress represents the single most important cause of disease, causing costs as high as 3-4 % of the European GNP, and up to 60% of all work-days lost to disease. Many of these diseases are related to infections and aberrant immune reactions. Our interest is in elucidating genetic, epigenetic, transcriptional, translation and post-translational mechanisms underlying environmental control of the stress reaction, particularly within the negative feedback loop of the HPA (hypothalamic–pituitary–adrenal) axis. 

The main goal of our research is to understand the molecular mechanisms underlying the environmental control of phenotype development, in the HPA axis and in the immune system. 


  • “Forschungsinstitut für Psychobiologie des Stresses” University Trier 
  • Research Unit INSIDE, University of Luxembourg 
  • Leiden-Amsterdam Centre for Drug Research (LACDR) 
  • Department of Periodontology University of Oslo & Department of Medical Psychology, Bergen, Norway 
  • Luxembourg Centre for Systems Biology (LCSB) 
  • Luxembourg Immune Mediated Inflammatory Disease Research Association (LIMIDRA) 
  • ZithaKlinik, Luxembourg 
  • Proteome and Genome Research Unit, LIH

Projects & clinical trials

Some of the group’s research projects include:

Featured team members

  • Nathalie
  • Jonathan
    Group leader

Scientific publications

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