Cancer is a priority disease for LIH and research efforts cover all its facets, with Precision Oncology at the heart of our efforts.
Our focus research areas include immuno-oncology, neuro-oncology, the tumour microenvironment, tumour metabolism and tumour genetics. Dedicated expertise is available for selected cancer types including brain cancers and haematological malignancies. In addition, LIH hosts Luxembourg’s National Cancer Registry (Registre National du Cancer, RNC), a core component of the national cancer control strategy. The RNC is a population-based cancer registry (PBCRs) and collects information from multiple sources on all new cancers diagnosed or treated in Luxembourg for public health and research purposes.
LIH investigates mechanistic processes that are fundamental for cancer initiation, progression and resistance to treatment. These include reciprocal crosstalk between tumour and non-neoplastic cells, cancer genetics and epigenetics, resistance to treatment, cancer metabolism and processes of invasion and metastasis.
The goal is to understand the biology of the disease in order to advance novel concepts from the prediction of response to therapy, the identification of novel targets for treatment to the development of innovative treatment approaches. A particular focus lies in developing and improving immunotherapies.
In parallel LIH has built up a strong expertise in selected cancer types, including brain cancer and blood malignancies.
For brain cancer, LIH focuses on malignant gliomas, including Glioblastoma (GBM), and brain metastases, leveraging on an in-house collection of more than 500 cross-sectional patient-derived tumour samples (PRECISION_PDX cohort). An extensive cohort of ex vivo and in vivo patient avatars has been generated and made publicly available. LIH also has a strong expertise in neuropathology through the PEARL chair in neuropathology leading to the creation of the Luxembourg Center of Neuropathology (LCNP).
In terms of haematological malignancies, LIH’s research activities concentrate on chronic lymphocytic leukaemia and the interaction of tumour cells with their microenvironment.
Through the Personalised Functional Profiling (PFP) project, dedicated to patients with GBM and gastro-intestinal cancers (GIC), we aim to deliver personalized treatment options based on upfront drug-response parameters determined on each patient’s tumour.
Several LIH research groups are currently working on this highly transversal priority area, integrating a broad set of in-house methodologies and capacities — ranging from ‘-omic’ approaches to patient-based models, risk factor identification, cancer epidemiology, exposure measurement and digital health expertise — thus studying the disease from different angles in a truly holistic way.
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
5 months 27 days
This cookie is set by the Google recaptcha service to identify bots to protect the website against malicious spam attacks.
Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Advertisement" category .
Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Analytics" category .
The cookie is set by the GDPR Cookie Consent plugin to record the user consent for the cookies in the category "Functional".
Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Necessary" category .
Set by the GDPR Cookie Consent plugin, this cookie is used to store the user consent for cookies in the category "Others".
Set by the GDPR Cookie Consent plugin, this cookie is used to store the user consent for cookies in the category "Performance".
Records the default button state of the corresponding category & the status of CCPA. It works only in coordination with the primary cookie.
The JSESSIONID cookie is used by New Relic to store a session identifier so that New Relic can monitor session counts for an application.
This cookie is native to PHP applications. The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website. The cookie is a session cookies and is deleted when all the browser windows are closed.
Analytical cookies are used to understand how visitors interact with the website. These cookies provide information on metrics such as number of visitors, bounce rate, traffic source, etc.
The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors.
This cookie is installed by Google Analytics.
Set by Google to distinguish users.
Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously.
Linkedin set this cookie to store information about the time a sync took place with the lms_analytics cookie.
YouTube sets this cookie via embedded youtube-videos and registers anonymous statistical data.