We aim to improve the treatment options for malignant brain tumors, with a focus on diffuse gliomas. With a radically translational approach to research, we work with patient samples and innovative patient-derived preclinical model systems that recapitulate the patient tumor. Our research investigates the cellular and molecular basis of gliomas, their capacity to invade the normal brain and escape therapy. Special areas of interests are tumor plasticity, tumor heterogeneity, tumor metabolism, immuno-oncology and pharmacogenomics.
Glioma patient avatars for personalized medicine
Immuno-competent tumor organoids
Personalized medicine and pharmacogenomics
Glioblastoma heterogeneity, plasticity and tumor-microenvironment interactions
IDH mutant glioma metabolism
Novel regulators of glioma invasion
Epigenetics, regulatory RNAs and functional genomics
Harnessing endogenous RTK inhibitors for anti-cancer treatment
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5 months 27 days
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