NORLUX Neuro-Oncology Laboratory
NORLUX is an interdisciplinary preclinical research group dedicated to exploring brain tumor biology towards identification of innovative biomarkers and novel treatment options for patients.
activities
We are dedicated to advancing treatment options for malignant brain tumors, with a specific focus on diffuse gliomas. With a radically translational approach to our research, we employ patient samples and innovative patient-derived preclinical model systems that faithfully reproduce the patient tumor. In our research, we investigate the cellular and molecular basis of gliomas, we explore their capacity to invade healthy brain tissue and escape therapy. Our overarching goal is to reveal novel therapeutic targets and identify reliable biomarkers of treatment responses.
SCIENTIFIC AREAS OF INTEREST AND ACTIVITIES
- Advanced brain tumor patient avatars for preclinical investigations and treatment efficacy studies
- Personalized medicine and pharmacogenomics
- Tumor heterogeneity at cellular, multi-omics and functional levels
- Tumor plasticity and resistance mechanisms
- Tumor-microenvironment interactions and immuno-oncology
Golebiewska
Patient cohorts and consortia
Funding Support
Please note that we are not currently recruiting for any Clinical Trials.
Projects & clinical trials
Featured team members
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Hamed
Allahverdi PhD Student -
Mirella
Baroni Milan Visiting Researcher -
Claire
Dording Laboratory Technician -
Anna
Golebiewska Group Leader -
Corey
Griffith Postdoctoral Fellow -
Iryna
Krokhmal Laboratory Technician -
Anuja
Lipsa Postdoctoral Fellow -
Beatriz
Monteiro Laboratory Assistant
Scientific publications
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Adenoviral delivery of the CIITA transgene induces T-cell-mediated killing in glioblastoma organoids – 13/11/2024
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Challenging the status quo to improve the translational potential of preclinical oncology studies – 07/10/2024
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Protocol using ex vivo mouse brain slice culture mimicking in vivo conditions to study tumor growth and cell motility of glioblastoma cells – 18/10/2024
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Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer – 18/11/2024
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Mapping extrachromosomal DNA amplifications during cancer progression – 14/10/2024
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Patient-based multilevel transcriptome exploration highlights relevant chemokines and chemokine receptor axes in glioblastoma – 30/09/2024
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Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis – 10/09/2024
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PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation – 16/07/2024
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AllergoOncology – 01/01/2024
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Most accurate mutations in SARS-CoV-2 genomes identified in Uzbek patients show novel amino acid changes – 31/05/2024
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