The DNA Repair and Chemoresistance research group focuses on the DNA repair and epigenetic mechanisms that operate in adult and pediatric glioblastoma (GBM) to identify critical targets for novel therapeutic strategies.
Beyond their role in preventing genetic instability and tumorigenesis, DNA repair and epigenetic mechanisms also contribute to the resistance of cancer cells to chemotherapeutic genotoxicants. These mechanisms are responsible in great part for the failure of current anti-glioma therapies. The DNA Repair and Chemoresistance research group is developing several approaches to better understand the DNA repair and epigenetic mechanisms that operate in adult and pediatric glioblastoma (GBM) and identify critical targets for novel therapeutic strategies. These approaches include:
A second line of investigation explores the molecular mechanisms governing the dynamics of heterochromatic regions and their impact on genomic stability in mammalian cells.
International collaborators include:
2020
2021