Department of Cancer Research
Our vision is to impact patients’ life by advancing the fight against cancer. Based on strong scientific track-records, we focus on priority research areas and provide research expertise covering the most common and/or malignant cancer types representing a health burden in Luxembourg. The department also represents a state-of-the-art training ground for next generation cancer researchers and acts as a reference point for cancer research in Luxembourg.
Mission
The main mission of the DoCR is to advance the treatment options of cancer and reduce the cancer burden within the Luxembourg population and beyond. It does so through research excellence in priority areas covering the basic, translational and clinical research landscape to foster personalised medicine programmes. Its activities focus on cancers which are difficult to treat. Its team, composed of multiple Research Groups, has dedicated expertise in cancer immunology, the tumour microenvironment, tumor metabolism and neuro-oncology. They explore the cellular and molecular mechanisms of tumor progression using a wide range of state-of-the-art technologies, including multimodal omics technologies (genomics, metabolomics…), advanced immunoprofiling analysis, as well as ex vivo and in vivo imaging modalities leveraging patient data and innovative patient-derived models for cancer research.
- Brain Imaging & Neuro Epidemiology, DoCR
- Cancer Metabolism Group
- Cancer RNAs and Epigenetic group
- Cytoskeleton and Cancer Progression
- DNA Repair and Chemoresistance
- In Vivo Imaging
- Metabolomics Platform
- Multiomics Data Science
- NORLUX Neuro-Oncology Laboratory
- Neuro-Immunology Group
- Translational Cancer Immunogenomics
- Tumor Immunotherapy and Microenvironment
- Tumor Stroma Interactions
VISIT OUR
RESEARCH PORTAL
The LIH Research Portal allows you to search and find information about all active researchers, units, outputs, projects and infrastructures.
Projects & clinical trials
Featured team members
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Corrado
Ameli Postdoctoral Fellow -
Rafael
Barros PhD Student -
Elisabetta
Bartolini PhD Student -
Michaela
Bauer Postdoctoral Fellow -
Amandine
Bernard Laboratory Technician -
Eleonora
Campus PhD Student -
Maryna
Chepeleva PhD Student -
Chloé
Duculty PhD Student
Scientific publications
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A comprehensive guide to study the immunological synapse using imaging flow cytometry – 03/04/2024
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Is the tumor cell side of the immunological synapse a polarized secretory domain? – 24/09/2024
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Actin remodeling in autophagy-mediated tumor immune escape, mechanistic aspects – 08/12/2023
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CSPG4 CAR-redirected Cytokine Induced Killer lymphocytes (CIK) as effective cellular immunotherapy for HLA class I defective melanoma – 22/11/2023
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Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse – 21/09/2023
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Correlative light and electron microscopy to explore the lytic immunological synapse between natural killer cells and cancer cells – 05/06/2023
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The Immunological Synapse Part B – 11/07/2023
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Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus – 15/05/2023
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Measuring CTL Lytic Granule Secretion and Target Cell Membrane Repair by Fluorescent Lipophilic Dye Uptake at the Lytic Synapse – 28/04/2023
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An integrated workflow for phosphopeptide identification in natural killer cells (NK-92MI) and their targets (MDA-MB-231) during immunological synapse formation – 09/02/2023
Related News
CANBIO
CANBIO is a doctoral research and training unit (DTU) addressing the clinical problem of tumour progression and recurrence. PhD candidates within CANBIO are engaged in a collaborative and interdisciplinary endeavour to deliver novel insight into tumour escape mechanisms, disease monitoring and large scale data analysis in highly malignant cancers.
i2TRON
TTM is taking a leading role in the coordination of i2TRON, a doctoral training unit (DTU) with a strong focus on developing the new generation of translational scientists, who can turn observations in the laboratory, clinical setting or community into interventions that improve the health of individuals via innovative diagnostics or treatments.
Visit the dedicated webpage for more information:
Job vacancies
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PhD Student in Cancer Epigenetics (JA/PHD0125/SF/CREG)
Department of Cancer Research – Cancer RNAs & Epigenetic Group
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Internship Position in Leukemia Research (Master’s students) – AL0425 (MC/ILR0425/AL/TSI)
Department of Cancer Research – Tumor Stroma Interactions