Immuno-pharmacology and interactomics
The Immuno-Pharmacology and Interactomics group focuses on the mechanisms that lead to cellular signaling disregulation and their impact in health and disease.
Altered cellular signalling and immune dysregulation are hallmarks of most auto-immune, inflammatory and chronic viral diseases. The expression, signalling and activity of chemokines and IFN are often altered in these pathologies but the molecular mechanisms and fine regulation at play are not completely understood. Most viruses have evolved strategies to hijack, bypass or lure these signal transducers and cellular effectors to favour their replication and/or to corrupt or evade immunity.
Our research interests revolve around two axes:
- Fundamental research aiming at gaining new insights into the complex structural and cellular mechanisms that lead to altered cellular signalling and cell transformation.
- Translational research aiming at developing novel tools and therapeutic approaches to interfere or modulate these processes and viral replication.
Projects & clinical trials
Some of the group’s research projects include:
- Studying the structure and function of human chemokine receptors CXCR4, CXCR7 and CXCR3 and viral receptors and deciphering homeostatic and pathogenic molecular interactions, signalling and intracellular trafficking induced by their endogenous and viral ligands.
- Designing novel chemokine-receptor inhibitors interfering with chemokine receptor signalling as well as with HIV entry and developing viral tools for applied research and for determining viral tropism as well as resistance to entry inhibitors.
- Studying the molecular mechanisms of HIV assembly and viral protein trafficking, paying particular care to the impact of subtype-related variability.
- Investigating the molecular mechanisms leading from chronic inflammation to cancer development in chronic viral infections, focusing on the role of the Interferon-induced proteins APOBEC3 and SAMHD1 in cellular DNA damage, viral integration of DNA viruses and cellular homeostasis.
Featured team members
Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE) – 09/02/2024
Systematic assessment of chemokine ligand bias at the human chemokine receptor CXCR2 indicates G protein bias over β-arrestin recruitment and receptor internalization – 17/01/2024
Reply to – 30/11/2023
Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern – 06/10/2023
G protein–receptor kinases 5/6 are the key regulators of G protein–coupled receptor 35–arrestin interactions – 01/09/2023
Formate promotes invasion and metastasis in reliance on lipid metabolism – 30/08/2023
Cannabidiol negatively modulates adenosine A2A receptor functioning in living cells – 01/01/2023
Inhibition of MYC translation through targeting of the newly identified PHB-EIF4F complex as therapeutic strategy inchronic lymphocytic leukemia (CLL) – 01/08/2023
GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity – 24/07/2023
Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL – 01/01/2023
There are no jobs matching this page at the moment. You can view all jobs via the button below.