Provide direct research support to the Biorefinery team, other research groups within LIH and future TMOH collaborators to address specific biospecimen-related issues that compromise the quality or efficiency of their work.
Carry out research that improves the efficiency by which clinical biospecimens are utilised by the research community and generally, enabling more research to be performed with less clinical material.
Disseminating the expertise of IBBL and LIH by publishing high quality Biospecimen Science Research papers and engaging with the global research community in matters relating to Biospecimen Science.
biorefinery (ISO 9001:2015 certification)
Method Validation and Implementation
Conducting pre-process/characterisation feasibility and optimisation of new technologies to establish best practices for biospecimen processing
Formal method validations and implementation of novel methods e.g. cfDNA and Exosomes isolations
Scientific Equipment Supervision: Implementation, validation and tracing the complete life cycle of scientific equipment
Highly standardised and automated processing of biospecimens from continuous routine and static clinical collections
Highly standardised and automated transformation and derivation of biospecimens
Highly specialised processing and characterisation e.g. 16S Sequencing, Elispot and ddPCR
All operations performed under fully traceable Laboratory Information Management System (LIMS)
Production Quality & Proficiency
Quality assessment, control and characterisation of biospecimens and derivatives (internal and external) applying ISO-17025 accredited methods
Provision of reference material for biorefinery routine processing
Proficiency testing programme provider: Assessment of participant compliance with international standards and good practices – FIND OUT MORE.
Technological advice, experimental design and training for flow cytometry, mass cytometry and imaging cytometry and microscopy
Instrument operations and / or realisation of complete experimental pipelines
Multidimensional data analysis from sample analysis to data integration and statistics
Histological processing of tissue samples
Digitalisation of microscopic images of samples
Pathological characterisation of tissue samples
Biorepository (ISO 9001:2015 certification)
As an accredited and certified biobank we operate under a strict quality management system and all our sample logistics and storage activities are carried out by experienced staff following standard operating procedures. We are equipped with 24/7 temperature monitoring and on-call staff, alarm systems, back-up freezers and generators, ensuring the security of your samples.
Study kit design & provision
Logistics of biological samples and study related goods in compliance with IATA regulations
Biological sample receipt, inventory and storage
Storage equipment and related environmental monitoring management
Translational biomarker group
Full-fledged or partial technical biomarker validation, encompassing three modules:
pre-analytical validation, to assess the most common pre-analytical variables undermining biomarker robustness
analytical validation, to verify method fitness-for-purpose
clinical verification, to perform a clinical validation on a smaller scale
Each module can be performed individually or in combination with another module.
Module sequence can be exchanged on a case-by-case BM scenario
Consultancy services for studies revolving around biomarker discovery, also in the context of grant applications Biomarker measurements, including platform bridging (ex.: qPCR to ddrPCR, ELISA to capillary Western Blot, etc.)
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