In vivo imaging
We provide preclinical imaging & advanced images analysis services to the Luxembourg Research Community and beyond.
Services
The mission of the In vivo Imaging Platform (IIP) is to provide preclinical in vivo imaging services to the scientific community. Different equipments are available, including a 3T MRI system, an Optical Imager and Analysis Workstations. We also provide access to a PET/CT system through a partnership with a long time collaborator.
The MRI and Optical Imager are located in the Specific Pathogen Free Animal Facility of the Luxembourg Institute of Health (LIH) in Luxembourg. Equipments needed for anesthesia, temperature control and physiological parameters monitoring are available at the facility.
The platform is commonly used today to validate in vitro experimental findings in preclinical models and to qualify promising new drugs or treatments paradigms before they are considered for clinical trials. Applications range from Oncology to Neuro-degenerative and Cardio-vascular diseases. All studies are subject to prior approval by the local Ethical Committee.
We provide assistance in setting up projects, optimizing imaging protocols & analysing data to those who need it. Experienced users can also use the platform autonomously provided they have the necessary accreditations and can demonstrate sufficient expertise in animal handling & imaging experimentation.
Technologies
- Magnetic Resonance Imaging
- Optical Imaging
- Positron Emission Tomography
- Images Analysis
Keunen
Featured team members
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Georgia
Kanli Research Engineer -
Olivier
Keunen Group Leader
Scientific publications
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Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model – 01/01/2023
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Author Correction – 26/01/2023
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Federated learning enables big data for rare cancer boundary detection – 05/12/2022
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Deciphering Human Glioblastoma Invasion Using a Developmental Mature Rat Brain Organoid Model – 15/11/2022
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The BET Protein Inhibitor JQ1 Decreases Hypoxia and Improves the Therapeutic Benefit of Anti-PD-1 in a High-Risk Neuroblastoma Mouse Model – 06/09/2022
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Federated Learning Enables Big Data for Rare Cancer Boundary Detection – 22/04/2022
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Molecular Identity Changes of Tumor-Associated Macrophages and Microglia after MRgFUS induced BBB Opening in a Mouse Glioblastoma Model – 15/03/2022
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Relationship between Metabolically Unhealthy Obesity and Visceral Adipose Tissue in Youth – 01/12/2021
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Current landscape and future perspectives in preclinical MR and PET imaging of brain metastasis – 14/10/2021
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Inhibition of GBM invasion by the A-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic acid (AMPA) Glutamate receptor antagonist Perampanel – 09/09/2021
