The immune system is integrated into the circuitry of every organ of the body, where it not only protects from infection, but helps to repair damaged tissue, removes cancer cells, helps to regulate metabolism, and serves as a conduit for communicating information throughout the body into all parts of our physiology. However, the immune system also has enormous capacity to wreak havoc on host tissues and organ function, if inappropriate or misdirected immune responses occur. Many of the maladies affecting humans today have an underlying immune component resulting from incorrect immune targeting associated with insufficient immune regulation. These include autoimmune diseases, allergies and infection-associated inflammatory damage (e.g. cytokine storm).
Nearly 90% of all immune cells in the body are associated with the gastrointestinal tract and these immune cells are continuously exposed to a wide range of microbes and microbial-derived compounds. Potent tolerance mechanisms ensure that these immune cells do not over-react, but instead they respond to infectious challenges in an robust, effective and well controlled manner. Recent changes in dietary habits and microbiota composition, especially evident in obese individuals, have resulted in reduced levels of immune regulatory metabolites that are expected and evolutionarily hardwired into our immune cell decision making processes. The lack of immune regulatory molecules results in a hypersensitive immune system that does not respond effectively to infection but is associated with a chronic state of inflammation that culminates in organ damage and disease for an increasing number of people.
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
5 months 27 days
This cookie is set by the Google recaptcha service to identify bots to protect the website against malicious spam attacks.
Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Advertisement" category .
Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Analytics" category .
The cookie is set by the GDPR Cookie Consent plugin to record the user consent for the cookies in the category "Functional".
Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Necessary" category .
Set by the GDPR Cookie Consent plugin, this cookie is used to store the user consent for cookies in the category "Others".
Set by the GDPR Cookie Consent plugin, this cookie is used to store the user consent for cookies in the category "Performance".
Records the default button state of the corresponding category & the status of CCPA. It works only in coordination with the primary cookie.
The JSESSIONID cookie is used by New Relic to store a session identifier so that New Relic can monitor session counts for an application.
This cookie is native to PHP applications. The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website. The cookie is a session cookies and is deleted when all the browser windows are closed.
Analytical cookies are used to understand how visitors interact with the website. These cookies provide information on metrics such as number of visitors, bounce rate, traffic source, etc.
The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors.
This cookie is installed by Google Analytics.
Set by Google to distinguish users.
Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously.
Linkedin set this cookie to store information about the time a sync took place with the lms_analytics cookie.
YouTube sets this cookie via embedded youtube-videos and registers anonymous statistical data.