Lecture - Molecular evolution under NeoAdjuvant chemotherapy- Prof Anne-Lise Børresen-Dale
17/03/2016 16:00 to 17/03/2016 18:15 (Europe/Luxembourg)
Prof Anne-Lise BØRRESEN-DALE is professor and Group leader in the Department of Cancer Genetics of the Institute for Cancer Research, Oslo, the University Hospital, The Norwegian Radiumhospital and the Institute for Clinical Medicine, Faculty of Medicine University of Oslo, Norway.
During this lecture, Prof Børresen-Dale will present conclusive data from the Neoadjuvant Avastin (NeoAva) study,a randomised phase II trial conducted with 132 HER2-negative breast cancer patients. The study aimed at investigating molecular alterations in breast tumours preoperatively treated with chemotherapy, with or without the antiangiogenic agent bevacizumab. Using magnetic resonance spectroscopy, high-throughput data was generated from serial biopsy samples collected at the time-point of diagnosis, during treatment and after surgical removal of the tumours. Different molecular levels were studied separately and combined in order to capture the changes during treatment of the two regimes and correlate the findings to response. The sub-clonal architecture of the tumours was also evaluated and revealed a clear sub type-specific response to treatment.
The results that will be presented in this lecture highlight the importance of dissecting the heterogeneity and molecular profile of a tumour at all levels during its evolution under treatment and demonstrate that sequential biopsies, although invasive, could have a major impact on patient prediction and prognosis.
About the Lecture & Workshop series - cancer research
The LIH lecture and workshops series in Cancer Research, supported by the FNR, are gathering internationally recognised speakers to address topics around Cancer Research. This lecture will be followed by a workshop especially dedicated to early-stage researchers.
Attendance to the lecture and workshop are free of charge. Should you be interested in registering for the workshop, please feel free to do so by sending us an email.