Activities
Our research is focused on malignant brain tumours and aims to improve therapeutic options for these uncurable cancers. Patient tumors and patient derived xenograft models (PDX), which enable to translate novel treatment approaches into personalised medicine, are central to our work. Ourspecific expertise and interests lie in tumour angiogenesis and invasion, tumour metabolism, and tumour cell heterogeneity and adaptability. Our research group is closely linked to the K.G. Jebsen Brain Tumour Research Center (University of Bergen, Norway), with joint research projects on glioma angiogenesis, metabolism and in vivo imaging, and has an extensive network of national and international collaborators.
Research projects
- ADAPT: Adaptive capacities of glioblastoma: is there a role for cancer stem cells?
- METABO: Aberrant tumour metabolism in gliomas.
- INVGBM: Targeting glioma cell invasion.
- CREG: Chemoresistance related RNAs in glioblastoma.
- ANIMIX: Establishment of a national in vivo imaging platform.
Featured Publications
Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts.
- NORLUX Neuro-Oncology Laboratory
- Woo XY
- Giordano J
- Srivastava A
- Zhao ZM
- Lloyd MW
- de Bruijn R
- Suh YS
- Patidar R
- Chen L
- Scherer S
- Bailey MH
- Yang CH
- Cortes-Sanchez E
- Xi Y
- Wang J
- Wickramasinghe J
- Kossenkov AV
- Rebecca VW
- Sun H
- Mashl RJ
- Davies SR
- Jeon R
- Frech C
- Randjelovic J
- Rosains J
- Galimi F
- Bertotti A
- Lafferty A
- O'Farrell AC
- Modave E
- Lambrechts D
- Ter Brugge P
- Serra V
- Marangoni E
- El Botty R
- Kim H
- Kim JI
- Yang HK
- Lee C
- Dean DA
- 2nd
- Davis-Dusenbery B
- Evrard YA
- Doroshow JH
- Welm AL
- Welm BE
- Lewis MT
- Fang B
- Roth JA
- Meric-Bernstam F
- Herlyn M
- Davies MA
- Ding L
- Li S
- Govindan R
- Isella C
- Moscow JA
- Trusolino L
- Byrne AT
- Jonkers J
- Bult CJ
- Medico E
- Chuang JH
- Pdxnet Consortium
- EurOPDX Consortium (Golebiewska A. and Niclou S.P. as collaborators for Luxembourg).
AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.
- NORLUX Neuro-Oncology Laboratory
- Multiomics Data Science
- Quantitative Biology Unit
- Proteomics of Cellular Signaling
- Schuster A
- Klein E
- Neirinckx V
- Knudsen AM
- Fabian C
- Hau AC
- Dieterle M
- Oudin A
- Nazarov PV
- Golebiewska A
- Muller A
- Perez-Hernandez D
- Rodius S
- Dittmar G
- Bjerkvig R
- Herold-Mende C
- Klink B
- Kristensen BW
- Niclou SP.
SIMONE NICLOU
84, Val Fleuri
L-1526 Luxembourg
Luxembourg
Tel. : (+352) 26 970