Our research is focused on malignant brain tumours and aims to improve therapeutic options for these uncurable cancers. Patient tumors and patient derived xenograft models (PDX), which enable to translate novel treatment approaches into personalised medicine, are central to our work.

Our specific expertise and interests lie in tumour angiogenesis and invasion, tumour metabolism, and tumour cell heterogeneity and adaptability. Our research group is closely linked to the K.G. Jebsen Brain Tumour Research Center (University of Bergen, Norway), with joint research projects on glioma angiogenesis, metabolism and in vivo imaging, and has an extensive network of national and international collaborators.

Research projects

  • ADAPT: Adaptive capacities of glioblastoma: is there a role for cancer stem cells?
  • METABO: Aberrant tumour metabolism in gliomas.
  • INVGBM: Targeting glioma cell invasion.
  • CREG: Chemoresistance related RNAs in glioblastoma.
  • ANIMIX: Establishment of a national in vivo imaging platform.
  • GLIOTRAIN: Exploiting GLIOblastoma intractability to address European research TRAINing needs in translational brain tumour research, cancer systems medicine and integrative multi-omics (GLIOTRAIN Newsletters)

Featured Publications

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.

  • Luxembourg Center of Neuropathology
  • Neuro-Oncology Laboratory
  • Computational Biomedecine
July 01, 2019
2019 Jul. Brain Pathol.29(4):513-529. Epub 2019 Jan 15.
  • Zeiner PS
  • Preusse C
  • Golebiewska A
  • Zinke J
  • Iriondo A
  • Muller A
  • Kaoma T
  • Filipski K
  • Muller-Eschner M
  • Bernatz S
  • Blank AE
  • Baumgarten P
  • Ilina E
  • Grote A
  • Hansmann ML
  • Verhoff MA
  • Franz K
  • Feuerhake F
  • Steinbach JP
  • Wischhusen J
  • Stenzel W
  • Niclou SP
  • Harter PN
  • Mittelbronn M.

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment.

  • Immuno-Pharmacology and Interactomics
  • Tumor Immunotherapy and Microenvironment
  • Neuro-Oncology Laboratory
June 18, 2019
2019 Jun. Cells.8(6).
  • Reynders N
  • Abboud D
  • Baragli A
  • Noman MZ
  • Rogister B
  • Niclou SP
  • Heveker N
  • Janji B
  • Hanson J
  • Szpakowska M
  • Chevigne A.
See all publications


Simone Niclou


84, rue Val Fleuri
L-1526 Luxembourg
Tel. : +352 26970-273