Activities

Our research group focuses first on how inflammation, allergic and autoimmune responses are controlled in the body’s periphery, and second, on how the same factors contribute to the development of lymphoma.

Protein ubiquitination, signaling to NF-ĸB and metabolic adaptations have in particular emerged as key mechanisms regulating immune homeostasis. How the differing signals triggered under various inflammatory conditions are integrated to ensure a coordinated immune response and maintenance of homeostasis is still only poorly understood. In that respect, we analyse regulatory circuits of the innate and adaptive immune system.

A better understanding of how inflammatory reactions are balanced will yield novel insights into the initiation and potential treatment of inflammatory diseases and hematological malignancies.

Research projects

  • Role of Th1, Th2, Th17 and regulatory T (Treg) cell subsets in mediating and mitigating inflammation.
  • Control of anaphylaxis by Treg cells.
  • Examine common pathways bridging the fields of inflammation and cancer biology.

Featured Publications

Regulatory T cell metabolism at the intersection between autoimmune diseases and cancer.

  • Experimental and Molecular Immunology
November 01, 2020
2020 Nov. Eur J Immunol.50(11):1626-1642. Epub 2020 Oct 26.
By:
  • Kurniawan H
  • Soriano-Baguet L
  • Brenner D.

Metabolic modulation of immunity: A new Concept in cancer immunotherapy.

  • Experimental and Molecular Immunology
July 07, 2020
2020 Jul. Cell Rep.32(1):107848.
By:
  • Guerra L
  • Bonetti L
  • Brenner D.
See all publications

Contacts

Dirk Brenner

M.S., Ph.D.

29, rue Henri Koch
L-4354Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-319