Our research group focuses first on how inflammation, allergic and autoimmune responses are controlled in the body’s periphery, and second, on how the same factors contribute to the development of lymphoma.

Protein ubiquitination, signaling to NF-ĸB and metabolic adaptations have in particular emerged as key mechanisms regulating immune homeostasis. How the differing signals triggered under various inflammatory conditions are integrated to ensure a coordinated immune response and maintenance of homeostasis is still only poorly understood. In that respect, we analyse regulatory circuits of the innate and adaptive immune system.

A better understanding of how inflammatory reactions are balanced will yield novel insights into the initiation and potential treatment of inflammatory diseases and hematological malignancies.

Research projects

  • Role of Th1, Th2, Th17 and regulatory T (Treg) cell subsets in mediating and mitigating inflammation.
  • Control of anaphylaxis by Treg cells.
  • Examine common pathways bridging the fields of inflammation and cancer biology.

Featured Publications

Survival of the fittest: Cancer challenges T cell metabolism.

  • Experimental and Molecular Immunology
  • Immune Systems Biology
January 01, 2018
2018 Jan. Cancer Lett.412:216-223. Epub 2017 Oct 24.
  • Franchina DG
  • He F
  • Brenner D.

TNF-mediated survival of CD169+ cells promotes immune activation during vesicular stomatitis virus infection.

  • Experimental and Molecular Immunology
November 15, 2017
2017 Nov. J Virol. [Epub ahead of print].
  • Shinde PV
  • Xu HC
  • Maney SK
  • Kloetgen A
  • Namineni S
  • Zhuang Y
  • Honke N
  • Shaabani N
  • Bellora N
  • Doerrenberg M
  • Trilling M
  • Pozdeev VI
  • van Rooijen N
  • Scheu S
  • Pfeffer K
  • Crocker PR
  • Tanaka M
  • Duggimpudi S
  • Knolle P
  • Heikenwalder M
  • Ruland J
  • Mak TW
  • Brenner D
  • Pandyra AA
  • Hoell JI
  • Borkhardt A
  • Haussinger D
  • Lang KS
  • Lang PA.
See all publications


Dirk Brenner

M.S., Ph.D.

29, rue Henri Koch
L-4354 Esch-sur-Alzette
Tel. : +352 26970-319