Activities

Our research group focuses first on how inflammation, allergic and autoimmune responses are controlled in the body’s periphery, and second, on how the same factors contribute to the development of lymphoma.

Protein ubiquitination, signaling to NF-ĸB and metabolic adaptations have in particular emerged as key mechanisms regulating immune homeostasis. How the differing signals triggered under various inflammatory conditions are integrated to ensure a coordinated immune response and maintenance of homeostasis is still only poorly understood. In that respect, we analyse regulatory circuits of the innate and adaptive immune system.

A better understanding of how inflammatory reactions are balanced will yield novel insights into the initiation and potential treatment of inflammatory diseases and hematological malignancies.

Research projects

  • Role of Th1, Th2, Th17 and regulatory T (Treg) cell subsets in mediating and mitigating inflammation.
  • Control of anaphylaxis by Treg cells.
  • Examine common pathways bridging the fields of inflammation and cancer biology.

Featured Publications

Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery.

  • Experimental and Molecular Immunology
May 01, 2019
2019 May. Eur J Immunol.(5):770-781. Epub 2019 Feb 20.
By:
  • Wilson AS
  • Law HD
  • Knobbe-Thomsen CB
  • Kearney CJ
  • Oliaro J
  • Binsfeld C
  • Burgio G
  • Starrs L
  • Brenner D
  • Randall KL
  • Brustle A.

Choline acetyltransferase-expressing T cells are required to control chronic viral infection.

  • Experimental and Molecular Immunology
February 08, 2019
2019 Feb. Science.363(6427):639-644.
By:
  • Cox MA
  • Duncan GS
  • Lin GHY
  • Steinberg BE
  • Yu LX
  • Brenner D
  • Buckler LN
  • Elia AJ
  • Wakeham AC
  • Nieman B
  • Dominguez-Brauer C
  • Elford AR
  • Gill KT
  • Kubli SP
  • Haight J
  • Berger T
  • Ohashi PS
  • Tracey KJ
  • Olofsson PS
  • Mak TW.
See all publications

Contact

Dirk Brenner

M.S., Ph.D.

29, rue Henri Koch
L-4354 Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-319