Activities

Our research group focuses first on how inflammation, allergic and autoimmune responses are controlled in the body’s periphery, and second, on how the same factors contribute to the development of lymphoma.

Protein ubiquitination, signaling to NF-ĸB and metabolic adaptations have in particular emerged as key mechanisms regulating immune homeostasis. How the differing signals triggered under various inflammatory conditions are integrated to ensure a coordinated immune response and maintenance of homeostasis is still only poorly understood. In that respect, we analyse regulatory circuits of the innate and adaptive immune system.

A better understanding of how inflammatory reactions are balanced will yield novel insights into the initiation and potential treatment of inflammatory diseases and hematological malignancies.

Research projects

  • Role of Th1, Th2, Th17 and regulatory T (Treg) cell subsets in mediating and mitigating inflammation.
  • Control of anaphylaxis by Treg cells.
  • Examine common pathways bridging the fields of inflammation and cancer biology.

Featured Publications

The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond.

  • Experimental and Molecular Immunology
January 01, 2019
2019 Jan. Physiol Rev.99(1):115-160.
By:
  • Dostert C
  • Grusdat M
  • Letellier E
  • Brenner D.

Structure and applications of novel influenza HA tri-stalk protein for evaluation of HA stem-specific immunity.

  • Vaccinology and B Cell Immunology
  • Experimental and Molecular Immunology
  • Eco-Immunology and Microbiome
September 27, 2018
2018 Sep. PLoS One.13(9):e0204776.
By:
  • Lu IN
  • Kirsteina A
  • Farinelle S
  • Willieme S
  • Tars K
  • Muller CP
  • Kazaks A.
See all publications

Contact

Dirk Brenner

M.S., Ph.D.

29, rue Henri Koch
L-4354 Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-319