Activities

Our research group focuses first on how inflammation, allergic and autoimmune responses are controlled in the body’s periphery, and second, on how the same factors contribute to the development of lymphoma.

Protein ubiquitination, signaling to NF-ĸB and metabolic adaptations have in particular emerged as key mechanisms regulating immune homeostasis. How the differing signals triggered under various inflammatory conditions are integrated to ensure a coordinated immune response and maintenance of homeostasis is still only poorly understood. In that respect, we analyse regulatory circuits of the innate and adaptive immune system.

A better understanding of how inflammatory reactions are balanced will yield novel insights into the initiation and potential treatment of inflammatory diseases and hematological malignancies.

Research projects

  • Role of Th1, Th2, Th17 and regulatory T (Treg) cell subsets in mediating and mitigating inflammation.
  • Control of anaphylaxis by Treg cells.
  • Examine common pathways bridging the fields of inflammation and cancer biology.

Featured Publications

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

  • Experimental and Molecular Immunology
  • Dimensional Immuno-Cytometry
October 01, 2019
2019 Oct. Eur J Immunol.49(10):1457-1973.
By:
  • Cossarizza A
  • Chang HD
  • Radbruch A
  • Acs A
  • Adam D
  • Adam-Klages S
  • Agace WW
  • Aghaeepour N
  • Akdis M
  • Allez M
  • Almeida LN
  • Alvisi G
  • Anderson G
  • Andra I
  • Annunziato F
  • Anselmo A
  • Bacher P
  • Baldari CT
  • Bari S
  • Barnaba V
  • Barros-Martins J
  • Battistini L
  • Bauer W
  • Baumgart S
  • Baumgarth N
  • Baumjohann D
  • Baying B
  • Bebawy M
  • Becher B
  • Beisker W
  • Benes V
  • Beyaert R
  • Blanco A
  • Boardman DA
  • Bogdan C
  • Borger JG
  • Borsellino G
  • Boulais PE
  • Bradford JA
  • Brenner D
  • Brinkman RR
  • Brooks AES
  • Busch DH
  • Buscher M
  • Bushnell TP
  • Calzetti F
  • Cameron G
  • Cammarata I
  • Cao X
  • Cardell SL
  • Casola S
  • Cassatella MA
  • Cavani A
  • Celada A
  • Chatenoud L
  • Chattopadhyay PK
  • Chow S
  • Christakou E
  • Cicin-Sain L
  • Clerici M
  • Colombo FS
  • Cook L
  • Cooke A
  • Cooper AM
  • Corbett AJ
  • Cosma A
  • Cosmi L
  • Coulie PG
  • Cumano A
  • Cvetkovic L
  • Dang VD
  • Dang-Heine C
  • Davey MS
  • Davies D
  • De Biasi S
  • Del Zotto G
  • Dela Cruz GV
  • Delacher M
  • Della Bella S
  • Dellabona P
  • Deniz G
  • Dessing M
  • Di Santo JP
  • Diefenbach A
  • Dieli F
  • Dolf A
  • Dorner T
  • Dress RJ
  • Dudziak D
  • Dustin M
  • Dutertre CA
  • Ebner F
  • Eckle SBG
  • Edinger M
  • Eede P
  • Ehrhardt GRA
  • Eich M
  • Engel P
  • Engelhardt B
  • Erdei A
  • Esser C
  • Everts B
  • Evrard M
  • Falk CS
  • Fehniger TA
  • Felipo-Benavent M
  • Ferry H
  • Feuerer M
  • Filby A
  • Filkor K
  • Fillatreau S
  • Follo M
  • Forster I
  • Foster J
  • Foulds GA
  • Frehse B
  • Frenette PS
  • Frischbutter S
  • Fritzsche W
  • Galbraith DW
  • Gangaev A
  • Garbi N
  • Gaudilliere B
  • Gazzinelli RT
  • Geginat J
  • Gerner W
  • Gherardin NA
  • Ghoreschi K
  • Gibellini L
  • Ginhoux F
  • Goda K
  • Godfrey DI
  • Goettlinger C
  • Gonzalez-Navajas JM
  • Goodyear CS
  • Gori A
  • Grogan JL
  • Grummitt D
  • Grutzkau A
  • Haftmann C
  • Hahn J
  • Hammad H
  • Hammerling G
  • Hansmann L
  • Hansson G
  • Harpur CM
  • Hartmann S
  • Hauser A
  • Hauser AE
  • Haviland DL
  • Hedley D
  • Hernandez DC
  • Herrera G
  • Herrmann M
  • Hess C
  • Hofer T
  • Hoffmann P
  • Hogquist K
  • Holland T
  • Hollt T
  • Holmdahl R
  • Hombrink P
  • Houston JP
  • Hoyer BF
  • Huang B
  • Huang FP
  • Huber JE
  • Huehn J
  • Hundemer M
  • Hunter CA
  • Hwang WYK
  • Iannone A
  • Ingelfinger F
  • Ivison SM
  • Jack HM
  • Jani PK
  • Javega B
  • Jonjic S
  • Kaiser T
  • Kalina T
  • Kamradt T
  • Kaufmann SHE
  • Keller B
  • Ketelaars SLC
  • Khalilnezhad A
  • Khan S
  • Kisielow J
  • Klenerman P
  • Knopf J
  • Koay HF
  • Kobow K
  • Kolls JK
  • Kong WT
  • Kopf M
  • Korn T
  • Kriegsmann K
  • Kristyanto H
  • Kroneis T
  • Krueger A
  • Kuhne J
  • Kukat C
  • Kunkel D
  • Kunze-Schumacher H
  • Kurosaki T
  • Kurts C
  • Kvistborg P
  • Kwok I
  • Landry J
  • Lantz O
  • Lanuti P
  • LaRosa F
  • Lehuen A
  • LeibundGut-Landmann S
  • Leipold MD
  • Leung LYT
  • Levings MK
  • Lino AC
  • Liotta F
  • Litwin V
  • Liu Y
  • Ljunggren HG
  • Lohoff M
  • Lombardi G
  • Lopez L
  • Lopez-Botet M
  • Lovett-Racke AE
  • Lubberts E
  • Luche H
  • Ludewig B
  • Lugli E
  • Lunemann S
  • Maecker HT
  • Maggi L
  • Maguire O
  • Mair F
  • Mair KH
  • Mantovani A
  • Manz RA
  • Marshall AJ
  • Martinez-Romero A
  • Martrus G
  • Marventano I
  • Maslinski W
  • Matarese G
  • Mattioli AV
  • Maueroder C
  • Mazzoni A
  • McCluskey J
  • McGrath M
  • McGuire HM
  • McInnes IB
  • Mei HE
  • Melchers F
  • Melzer S
  • Mielenz D
  • Miller SD
  • Mills KHG
  • Minderman H
  • Mjosberg J
  • Moore J
  • Moran B
  • Moretta L
  • Mosmann TR
  • Muller S
  • Multhoff G
  • Munoz LE
  • Munz C
  • Nakayama T
  • Nasi M
  • Neumann K
  • Ng LG
  • Niedobitek A
  • Nourshargh S
  • Nunez G
  • O'Connor JE
  • Ochel A
  • Oja A
  • Ordonez D
  • Orfao A
  • Orlowski-Oliver E
  • Ouyang W
  • Oxenius A
  • Palankar R
  • Panse I
  • Pattanapanyasat K
  • Paulsen M
  • Pavlinic D
  • Penter L
  • Peterson P
  • Peth C
  • Petriz J
  • Piancone F
  • Pickl WF
  • Piconese S
  • Pinti M
  • Pockley AG
  • Podolska MJ
  • Poon Z
  • Pracht K
  • Prinz I
  • Pucillo CEM
  • Quataert SA
  • Quatrini L
  • Quinn KM
  • Radbruch H
  • Radstake T
  • Rahmig S
  • Rahn HP
  • Rajwa B
  • Ravichandran G
  • Raz Y
  • Rebhahn JA
  • Recktenwald D
  • Reimer D
  • Reis ESC
  • Remmerswaal EBM
  • Richter L
  • Rico LG
  • Riddell A
  • Rieger AM
  • Robinson JP
  • Romagnani C
  • Rubartelli A
  • Ruland J
  • Saalmuller A
  • Saeys Y
  • Saito T
  • Sakaguchi S
  • Sala-de-Oyanguren F
  • Samstag Y
  • Sanderson S
  • Sandrock I
  • Santoni A
  • Sanz RB
  • Saresella M
  • Sautes-Fridman C
  • Sawitzki B
  • Schadt L
  • Scheffold A
  • Scherer HU
  • Schiemann M
  • Schildberg FA
  • Schimisky E
  • Schlitzer A
  • Schlosser J
  • Schmid S
  • Schmitt S
  • Schober K
  • Schraivogel D
  • Schuh W
  • Schuler T
  • Schulte R
  • Schulz AR
  • Schulz SR
  • Scotta C
  • Scott-Algara D
  • Sester DP
  • Shankey TV
  • Silva-Santos B
  • Simon AK
  • Sitnik KM
  • Sozzani S
  • Speiser DE
  • Spidlen J
  • Stahlberg A
  • Stall AM
  • Stanley N
  • Stark R
  • Stehle C
  • Steinmetz T
  • Stockinger H
  • Takahama Y
  • Takeda K
  • Tan L
  • Tarnok A
  • Tiegs G
  • Toldi G
  • Tornack J
  • Traggiai E
  • Trebak M
  • Tree TIM
  • Trotter J
  • Trowsdale J
  • Tsoumakidou M
  • Ulrich H
  • Urbanczyk S
  • van de Veen W
  • van den Broek M
  • van der Pol E
  • Van Gassen S
  • Van Isterdael G
  • van Lier RAW
  • Veldhoen M
  • Vento-Asturias S
  • Vieira P
  • Voehringer D
  • Volk HD
  • von Borstel A
  • von Volkmann K
  • Waisman A
  • Walker RV
  • Wallace PK
  • Wang SA
  • Wang XM
  • Ward MD
  • Ward-Hartstonge KA
  • Warnatz K
  • Warnes G
  • Warth S
  • Waskow C
  • Watson JV
  • Watzl C
  • Wegener L
  • Weisenburger T
  • Wiedemann A
  • Wienands J
  • Wilharm A
  • Wilkinson RJ
  • Willimsky G
  • Wing JB
  • Winkelmann R
  • Winkler TH
  • Wirz OF
  • Wong A
  • Wurst P
  • Yang JHM
  • Yang J
  • Yazdanbakhsh M
  • Yu L
  • Yue A
  • Zhang H
  • Zhao Y
  • Ziegler SM
  • Zielinski C
  • Zimmermann J
  • Zychlinsky A.

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury.

  • Experimental and Molecular Immunology
August 13, 2019
2019 Aug. Gut. [Epub ahead of print].
By:
  • Zhuang Y
  • Xu HC
  • Shinde PV
  • Warfsmann J
  • Vasilevska J
  • Sundaram B
  • Behnke K
  • Huang J
  • Hoell JI
  • Borkhardt A
  • Pfeffer K
  • Taha MS
  • Herebian D
  • Mayatepek E
  • Brenner D
  • Ahmadian MR
  • Keitel V
  • Wieczorek D
  • Haussinger D
  • Pandyra AA
  • Lang KS
  • Lang PA.
See all publications

Contacts

Dirk Brenner

M.S., Ph.D.

29, rue Henri Koch
L-4354 Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-319