Activities

Our research group focuses first on how inflammation, allergic and autoimmune responses are controlled in the body’s periphery, and second, on how the same factors contribute to the development of lymphoma.

Protein ubiquitination, signaling to NF-ĸB and metabolic adaptations have in particular emerged as key mechanisms regulating immune homeostasis. How the differing signals triggered under various inflammatory conditions are integrated to ensure a coordinated immune response and maintenance of homeostasis is still only poorly understood. In that respect, we analyse regulatory circuits of the innate and adaptive immune system.

A better understanding of how inflammatory reactions are balanced will yield novel insights into the initiation and potential treatment of inflammatory diseases and hematological malignancies.

Research projects

  • Role of Th1, Th2, Th17 and regulatory T (Treg) cell subsets in mediating and mitigating inflammation.
  • Control of anaphylaxis by Treg cells.
  • Examine common pathways bridging the fields of inflammation and cancer biology.

Featured Publications

Assessment of 9-OH- and 7,8-diol-benzo[a]pyrene in blood as potent markers of cognitive impairment related to benzo[a]pyrene exposure: An animal model study.

  • Immune Endocrine and Epigenetics
  • Experimental and Molecular Immunology
  • Clinical and Applied Virology
March 08, 2021
2021 Mar. Toxics.9(3):50.
By:
  • Cherif LS
  • Cao-Lei L
  • Farinelle S
  • Muller CP
  • Turner JD
  • Schroeder H
  • Grova N.

The emerging role of one-carbon metabolism in T cells.

  • Experimental and Molecular Immunology
January 07, 2021
2021 Jan. Curr Opin Biotechnol.68:193-201.
By:
  • Kurniawan H
  • Kobayashi T
  • Brenner D.
See all publications

Contacts

Dirk Brenner

M.S., Ph.D.

29, rue Henri Koch
L-4354Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-319