Activities

Our research group focuses first on how inflammation, allergic and autoimmune responses are controlled in the body’s periphery, and second, on how the same factors contribute to the development of lymphoma.

Protein ubiquitination, signaling to NF-ĸB and metabolic adaptations have in particular emerged as key mechanisms regulating immune homeostasis. How the differing signals triggered under various inflammatory conditions are integrated to ensure a coordinated immune response and maintenance of homeostasis is still only poorly understood. In that respect, we analyse regulatory circuits of the innate and adaptive immune system.

A better understanding of how inflammatory reactions are balanced will yield novel insights into the initiation and potential treatment of inflammatory diseases and hematological malignancies.

Research projects

  • Role of Th1, Th2, Th17 and regulatory T (Treg) cell subsets in mediating and mitigating inflammation.
  • Control of anaphylaxis by Treg cells.
  • Examine common pathways bridging the fields of inflammation and cancer biology.

Featured Publications

Glutathione restricts serine metabolism to preserve Regulatory T cell function.

  • Experimental and Molecular Immunology
  • Allergy and Clinical Immunology
  • Immune Endocrine and Epigenetics
  • Cancer Metabolism Group
March 16, 2020
2020 Mar. Cell Metab. [Epub ahead of print].
By:
  • Kurniawan H
  • Franchina DG
  • Guerra L
  • Bonetti L
  • Baguet LS
  • Grusdat M
  • Schlicker L
  • Hunewald O
  • Dostert C
  • Merz MP
  • Binsfeld C
  • Duncan GS
  • Farinelle S
  • Nonnenmacher Y
  • Haight J
  • Das Gupta D
  • Ewen A
  • Taskesen R
  • Halder R
  • Chen Y
  • Jager C
  • Ollert M
  • Wilmes P
  • Vasiliou V
  • Harris IS
  • Knobbe-Thomsen CB
  • Turner JD
  • Mak TW
  • Lohoff M
  • Meiser J
  • Hiller K
  • Brenner D.

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury.

  • Experimental and Molecular Immunology
January 01, 2020
2020 Jan. Gut.69(1):133-145. Epub 2019 Aug 13.
By:
  • Zhuang Y
  • Xu HC
  • Shinde PV
  • Warfsmann J
  • Vasilevska J
  • Sundaram B
  • Behnke K
  • Huang J
  • Hoell JI
  • Borkhardt A
  • Pfeffer K
  • Taha MS
  • Herebian D
  • Mayatepek E
  • Brenner D
  • Ahmadian MR
  • Keitel V
  • Wieczorek D
  • Haussinger D
  • Pandyra AA
  • Lang KS
  • Lang PA.
See all publications

Contacts

Dirk Brenner

M.S., Ph.D.

29, rue Henri Koch
L-4354 Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-319