Activities

Our research group focuses first on how inflammation, allergic and autoimmune responses are controlled in the body’s periphery, and second, on how the same factors contribute to the development of lymphoma.

Protein ubiquitination, signaling to NF-ĸB and metabolic adaptations have in particular emerged as key mechanisms regulating immune homeostasis. How the differing signals triggered under various inflammatory conditions are integrated to ensure a coordinated immune response and maintenance of homeostasis is still only poorly understood. In that respect, we analyse regulatory circuits of the innate and adaptive immune system.

A better understanding of how inflammatory reactions are balanced will yield novel insights into the initiation and potential treatment of inflammatory diseases and hematological malignancies.

Research projects

  • Role of Th1, Th2, Th17 and regulatory T (Treg) cell subsets in mediating and mitigating inflammation.
  • Control of anaphylaxis by Treg cells.
  • Examine common pathways bridging the fields of inflammation and cancer biology.

Featured Publications

Reactive Oxygen species: Involvement in T cell signaling and metabolism.

  • Experimental and Molecular Immunology
June 01, 2018
2018 Jun. Trends Immunol.39(6):489-502. Epub 2018 Feb 13.
By:
  • Franchina DG
  • Dostert C
  • Brenner D.

Applying unique molecular identifiers in next generation sequencing reveals a constrained viral quasispecies evolution under cross-reactive antibody pressure targeting long alpha helix of hemagglutinin.

  • Vaccinology and B Cell Immunology
  • Experimental and Molecular Immunology
  • Immune Systems Biology
March 25, 2018
2018 Mar. Viruses.10(4).
By:
  • Hauck NC
  • Kirpach J
  • Kiefer C
  • Farinelle S
  • Maucourant S
  • Morris SA
  • Rosenberg W
  • He FQ
  • Muller CP
  • Lu IN.
See all publications

Contact

Dirk Brenner

M.S., Ph.D.

29, rue Henri Koch
L-4354 Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-319