bioinformatics (bioinfo) platform
The Bioinformatics Platform provides top of the line bioinformatics services to the research groups of the LIH and other collaborating partners.
activities
The Bioinformatics platform focuses on analysis centered around multi-omics data, their integration, statistical analysis, developing predictive models and presentation of the results in relevant figures. When needed, additional clinical data are considered and integrated with multi-omics data. The Bioinformatics platform also provides training in a variety of disciplines: biostatistics, R programming, data science, transcriptomics data analysis and machine learning.
PETR
NAZAROV
NAZAROV
Projects & clinical trials
The group members contributed to the following research projects at LIH in the past two years:
- “A diagnostic test to improve surveillance and care of COVID-19 patients” (COVIRNA), EU Horizon 2020 Research and Innovation Programme, 2020-2023.
- “Glioma longitudinal analysis in Luxembourg: ex vivo and in vivo functional profiling of recurrent gliomas” (GLASS-LUX), FNR, 2021-2024.
- “Predicting the severity of COVID-19 infection” (Predi-COVID), FNR, Andre Losch Foundation, Luxembourg Institute of Health, The Government of Luxembourg.
- “Decomposition of mixed transcriptomes for classification of heterogeneous tumour samples (DEMICS)”, Luxembourg’s National Research Fund (FNR), 2018-2020.
- “Peptide, protein, single-cell map of the renin-angiotensin system in Covid-19” (RAS CoV-2), FNR Fast Track program, 2020
Featured team members
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Vladimir
Despotovic Scientist in Health Data -
Tony
Kaoma Mukendi Bioinformatician -
Sang Yoon
Kim Bioinformatician -
Arnaud
Muller Bioinformatician -
Petr
Nazarov Group Leader -
Reka
Toth Scientist -
Lu
Zhang Research Engineer
Scientific publications
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Vocal biomarker predicts fatigue in people with COVID-19 – 22/11/2022
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Discovery and analytical validation of a vocal biomarker to monitor anosmia and ageusia in patients with Covid-19 – 07/09/2022
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Circular RNAs to predict clinical outcome after cardiac arrest – 28/10/2022
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Allergic airway inflammation delays glioblastoma progression and reinvigorates systemic and local immunity in mice – 01/01/2022
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Audio-based Active and Assisted Living – 25/08/2022
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Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency – 01/01/2022
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Proteomic profiling of idiopathic Parkinson’s disease primary patient cells by SWATH-MS – 01/01/2022
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Club cells employ regeneration mechanisms during lung tumorigenesis – 05/08/2022
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Long COVID Symptomatology After 12 Months and Its Impact on Quality of Life According to Initial Coronavirus Disease 2019 Disease Severity – 05/08/2022
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Neurodegeneration and neuroinflammation are linked, but independent of alpha-synuclein inclusions, in a seeding/spreading mouse model of Parkinson’s disease – 29/01/2022
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Long COVID Classification: Findings from a Clustering Analysis in the Predi-COVID Cohort Study – 01/01/2022
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Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia – 01/01/2021
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Allergic airway inflammation impacts tumor take and delays experimental glioblastoma progression – 01/09/2021
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The circadian clock remains intact, but with dampened hormonal output in heart failure – 01/09/2021
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Towards precision cardiometabolic prevention – 06/08/2021
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Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia – 03/05/2021
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Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers – 18/03/2021
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The Long Noncoding RNA Landscape of Cardiac Regeneration in Zebrafish – 01/03/2021
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A New Synuclein-Transgenic Mouse Model for Early Parkinson’s Reveals Molecular Features of Preclinical Disease – 01/02/2021
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Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells – 18/01/2021
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