bioinformatics (bioinfo) platform
The Bioinformatics Platform provides top of the line bioinformatics services to the research groups of the LIH and other collaborating partners.
activities
The Bioinformatics platform focuses on analysis centered around multi-omics data, their integration, statistical analysis, developing predictive models and presentation of the results in relevant figures. When needed, additional clinical data are considered and integrated with multi-omics data. The Bioinformatics platform also provides training in a variety of disciplines: biostatistics, R programming, data science, transcriptomics data analysis and machine learning.
PETR
NAZAROV
NAZAROV
Projects & clinical trials
The group members contributed to the following research projects at LIH in the past two years:
- “A diagnostic test to improve surveillance and care of COVID-19 patients” (COVIRNA), EU Horizon 2020 Research and Innovation Programme, 2020-2023.
- “Glioma longitudinal analysis in Luxembourg: ex vivo and in vivo functional profiling of recurrent gliomas” (GLASS-LUX), FNR, 2021-2024.
- “Predicting the severity of COVID-19 infection” (Predi-COVID), FNR, Andre Losch Foundation, Luxembourg Institute of Health, The Government of Luxembourg.
- “Decomposition of mixed transcriptomes for classification of heterogeneous tumour samples (DEMICS)”, Luxembourg’s National Research Fund (FNR), 2018-2020.
- “Peptide, protein, single-cell map of the renin-angiotensin system in Covid-19” (RAS CoV-2), FNR Fast Track program, 2020
Featured team members
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Vladimir
Despotovic Scientist in Health Data -
Feng
He Scientist -
Tony
Kaoma Mukendi Bioinformatician -
Sang Yoon
Kim Bioinformatician -
Arnaud
Muller Bioinformatician -
Petr
Nazarov Group Leader -
Reka
Toth Scientist -
Lu
Zhang Research Engineer
Scientific publications
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The circadian clock remains intact, but with dampened hormonal output in heart failure – 17/04/2023
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Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking – 22/03/2023
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Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL – 01/01/2023
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Altered infective competence of the human gut microbiome in COVID-19 – 09/03/2023
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Glioblastoma-instructed microglia transit to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 06/03/2023
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Maternal diet and gut microbiome composition modulate early life immune responses – 06/03/2023
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Stabilization of Stochastic Dynamical Systems of a Random Structure with Markov Switches and Poisson Perturbations – 01/02/2023
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Correction – 31/01/2023
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Machine learning for predicting neurodegenerative diseases in the general older population – 11/01/2023
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FIMICS – 01/01/2023
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