Tumor Stroma Interactions
The Tumor Stroma Interactions group studies the mechanisms leading to leukemia progression.
Activities
The Tumor Stroma Interactions research group is a dynamic and international team studying the mechanisms that lead to leukemia with the goal of identifying new predictive markers and therapeutic targets.
Some of the group’s research projects include:
- New therapeutic targets in CLL – investigating the therapeutic efficacy and mode of action of new molecules that inhibit the cellular metabolism or the translation machinery in chronic lymphocytic leukemia (CLL), both in patient cells and in murine models.
- Tumor immunology – identifying new cellular populations which could be used as biomarkers for response to treatments as well as new potential therapeutic targets.
- Exosomes in B-cell malignancies – identifying potential biomarkers in exosomes derived from murine preclinical models and the cells of patients affected by hematologic malignancies as well as testing their influence on cells from the microenvironment.
- New models to study leukemia – developing 2D and 3D models of co-culture that allow for leukemic cell survival and improving PDX murine models of CLL, enabling testing of new therapeutic strategies in relevant conditions.
Collaborations
Projects & clinical trials
Featured team members
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Rafael
Barros PhD Student -
Michaela
Bauer Postdoctoral Fellow -
Chloé
Duculty PhD Student -
Ozgu
Gumustekin PhD Student -
Vanessa
Klapp PhD Student -
Chloé
Lamiraux Laboratory Assistant -
Anne
Largeot Scientist -
Etienne
Moussay Group Leader
Scientific publications
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Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemia – 01/01/2025
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Restoring NK Cell Cytotoxicity Post-Cryopreservation via Synthetic Cells – 18/09/2025
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Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target – 07/08/2025
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Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia – 01/12/2024
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The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency – 08/10/2024
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Protocol for isolating leukemia-derived extracellular vesicles from the spleen of preclinical models of leukemia using ultracentrifugation – 05/08/2024
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Characterization of the tumor and its microenvironment in chronic lymphocytic leukemia – 14/05/2024
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Editorial – 08/05/2024
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PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle – 28/02/2024
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Minimal information for studies of extracellular vesicles (MISEV2023) – 01/02/2024
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