Tumor Stroma Interactions

Activities

The Tumor Stroma Interactions research group is a dynamic and international team studying the mechanisms that lead to leukemia with the goal of identifying new predictive markers and therapeutic targets. 

Some of the group’s research projects include: 

• New therapeutic targets in CLL – investigating the therapeutic efficacy and mode of action of new molecules that inhibit the cellular metabolism or the translation machinery in chronic lymphocytic leukemia (CLL), both in patient cells and in murine models. 
• Tumor immunology – identifying new cellular populations which could be used as biomarkers for response to treatments as well as new potential therapeutic targets. 
• Exosomes in B-cell malignancies – identifying potential biomarkers in exosomes derived from murine preclinical models and the cells of patients affected by hematologic malignancies as well as testing their influence on cells from the microenvironment. 
• New models to study leukemia – developing 2D and 3D models of co-culture that allow for leukemic cell survival and improving PDX murine models of CLL, enabling testing of new therapeutic strategies in relevant conditions.

Group Leaders