Activities

The Bioinformatics and Modelling group’s vision is to enable benefits for patients through integrated computational and biological modeling. The main objective is to enable translationally-oriented research through strong collaborations at the LIH and abroad. This requires making sense of the large and complex datasets obtained from patients, animal and cell line models. The group’s top priority is the development of novel computational models for cancer patient stratification and drug response prediction using multi-omics data. The scientists within the group lead and enable cross-disciplinary research partnerships, which benefit from their diverse expertise in: a. Biological network modeling and analysis; c. Integrative, large-scale analysis of multi-omics data; and C. Biostatistics and machine learning.

Research projects

  • “Drug repositioning for the treatment of myocardial infarction through systems biology approaches (INFUSED)”, Luxembourg’s National Research Fund (FNR) / Swiss National Science Foundation (SNSF).
  • “Non-coding RNA regulatory circuits in glioma” (CIRCUITOMA), FNR, INTER programme.
  • “New tools for the prediction of influential nodes and links in multi-level cancer-related networks”, FNR, Luxembourg-Singapore cooperation programme, 2016-2018

Featured Publications

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Neuro-Immunology Group
  • Computational Biomedicine
  • Multiomics Data Science
  • Luxembourg Center of Neuropathology
  • Personalized Drug Discovery
October 03, 2020
2020 Oct. Acta Neuropathol. Online ahead of print.
By:
  • Golebiewska A
  • Hau AC
  • Oudin A
  • Stieber D
  • Yabo YA
  • Baus V
  • Barthelemy V
  • Klein E
  • Bougnaud S
  • Keunen O
  • Wantz M
  • Michelucci A
  • Neirinckx V
  • Muller A
  • Kaoma T
  • Nazarov PV
  • Azuaje F
  • De Falco A
  • Flies B
  • Richart L
  • Poovathingal S
  • Arns T
  • Grzyb K
  • Mock A
  • Herold-Mende C
  • Steino A
  • Brown D
  • May P
  • Miletic H
  • Malta TM
  • Noushmehr H
  • Kwon YJ
  • Jahn W
  • Klink B
  • Tanner G
  • Stead LF
  • Mittelbronn M
  • Skupin A
  • Hertel F
  • Bjerkvig R
  • Niclou SP.

Extracellular ATP and CD39 activate cAMP-mediated mitochondrial stress response to promote cytarabine resistance in acute myeloid leukemia.

  • Quantitative Biology Unit
  • Computational Biomedicine
October 01, 2020
2020 Oct. Cancer Discov.10(10):1544-1565. Epub 2020 Jul 8.
By:
  • Aroua N
  • Boet E
  • Ghisi M
  • Nicolau-Travers ML
  • Saland E
  • Gwilliam R
  • de Toni F
  • Hosseini M
  • Mouchel PL
  • Farge T
  • Bosc C
  • Stuani L
  • Sabatier M
  • Mazed F
  • Larrue C
  • Jarrou L
  • Gandarillas S
  • Bardotti M
  • Picard M
  • Syrykh C
  • Laurent C
  • Gotanegre M
  • Bonnefoy N
  • Bellvert F
  • Portais JC
  • Nicot N
  • Azuaje F
  • Kaoma T
  • Joffre C
  • Tamburini J
  • Recher C
  • Vergez F
  • Sarry JE.
See all publications

Contacts

Petr Nazarov

Ph.D.

1A-B, rue Thomas Edison
1445Strassen
Luxembourg
Tel. : +352 26970-385