Activities

The Bioinformatics and Modelling group’s vision is to enable benefits for patients through integrated computational and biological modeling. The main objective is to enable translationally-oriented research through strong collaborations at the LIH and abroad. This requires making sense of the large and complex datasets obtained from patients, animal and cell line models. The group’s top priority is the development of novel computational models for cancer patient stratification and drug response prediction using multi-omics data. The scientists within the group lead and enable cross-disciplinary research partnerships, which benefit from their diverse expertise in: a. Biological network modeling and analysis; c. Integrative, large-scale analysis of multi-omics data; and C. Biostatistics and machine learning.

Research projects

  • “Drug repositioning for the treatment of myocardial infarction through systems biology approaches (INFUSED)”, Luxembourg’s National Research Fund (FNR) / Swiss National Science Foundation (SNSF).
  • “Non-coding RNA regulatory circuits in glioma” (CIRCUITOMA), FNR, INTER programme.
  • “New tools for the prediction of influential nodes and links in multi-level cancer-related networks”, FNR, Luxembourg-Singapore cooperation programme, 2016-2018

Featured Publications

Standardization of the preanalytical phase of DNA extraction from fixed tissue for next-generation sequencing analyses.

  • Computational Biomedicine
January 25, 2020
2020 Jan. N Biotechnol.54:52-61. Epub 2019 Aug 6.
By:
  • Kofanova O
  • Bellora C
  • Garcia Frasquilho S
  • Antunes L
  • Hamot G
  • Mathay C
  • Mommaerts K
  • Muller A
  • DeWitt B
  • Betsou F.

Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software.

  • Computational Biomedicine
January 13, 2020
2020 Jan. BMC Bioinformatics.21(1):16.
By:
  • Decamps C
  • Prive F
  • Bacher R
  • Jost D
  • Waguet A
  • Hadaca consortium (Kaoma T and Nazarov P as collaborators)
  • Houseman EA
  • Lurie E
  • Lutsik P
  • Milosavljevic A
  • Scherer M
  • Blum MGB
  • Richard M.
See all publications

Contacts

Petr Nazarov

Ph.D.

1A-B, rue Thomas Edison
1445 Strassen
Luxembourg
Tel. : +352 26970-385