The Bioinformatics and Modelling group’s vision is to enable benefits for patients through integrated computational and biological modeling. The main objective is to enable translationally-oriented research through strong collaborations at the LIH and abroad. This requires making sense of the large and complex datasets obtained from patients, animal and cell line models. The group’s top priority is the development of novel computational models for cancer patient stratification and drug response prediction using multi-omics data. The scientists within the group lead and enable cross-disciplinary research partnerships, which benefit from their diverse expertise in: a. Biological network modeling and analysis; c. Integrative, large-scale analysis of multi-omics data; and C. Biostatistics and machine learning.

Research projects

  • “Drug repositioning for the treatment of myocardial infarction through systems biology approaches (INFUSED)”, Luxembourg’s National Research Fund (FNR) / Swiss National Science Foundation (SNSF).
  • “Non-coding RNA regulatory circuits in glioma” (CIRCUITOMA), FNR, INTER programme.
  • “New tools for the prediction of influential nodes and links in multi-level cancer-related networks”, FNR, Luxembourg-Singapore cooperation programme, 2016-2018

Featured Publications

A new synuclein-transgenic mouse model for early Parkinson's reveals molecular features of preclinical disease.

  • Quantitative Biology Unit
  • Computational Biomedicine
February 01, 2021
2021 Feb. Mol Neurobiol.58(2):576-602. Epub 2020 Sep 30.
  • Hendrickx DM
  • Garcia P
  • Ashrafi A
  • Sciortino A
  • Schmit KJ
  • Kollmus H
  • Nicot N
  • Kaoma T
  • Vallar L
  • Buttini M
  • Glaab E.

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

  • NORLUX Neuro-Oncology Laboratory
  • Translational Radiomics
  • Neuro-Immunology Group
  • Computational Biomedicine
  • Multiomics Data Science
  • Luxembourg Center of Neuropathology
  • Personalized Therapy Discovery
December 01, 2020
2020 Dec. Acta Neuropathol.140(6):919-949. Epub 2020 Oct 3.
  • Golebiewska A
  • Hau AC
  • Oudin A
  • Stieber D
  • Yabo YA
  • Baus V
  • Barthelemy V
  • Klein E
  • Bougnaud S
  • Keunen O
  • Wantz M
  • Michelucci A
  • Neirinckx V
  • Muller A
  • Kaoma T
  • Nazarov PV
  • Azuaje F
  • De Falco A
  • Flies B
  • Richart L
  • Poovathingal S
  • Arns T
  • Grzyb K
  • Mock A
  • Herold-Mende C
  • Steino A
  • Brown D
  • May P
  • Miletic H
  • Malta TM
  • Noushmehr H
  • Kwon YJ
  • Jahn W
  • Klink B
  • Tanner G
  • Stead LF
  • Mittelbronn M
  • Skupin A
  • Hertel F
  • Bjerkvig R
  • Niclou SP.
See all publications


Petr Nazarov


1A-B, rue Thomas Edison
Tel. : +352 26970-385