Activities

The Bioinformatics and Modelling group’s vision is to enable benefits for patients through integrated computational and biological modeling. The main objective is to enable translationally-oriented research through strong collaborations at the LIH and abroad. This requires making sense of the large and complex datasets obtained from patients, animal and cell line models. The group’s top priority is the development of novel computational models for cancer patient stratification and drug response prediction using multi-omics data. The scientists within the group lead and enable cross-disciplinary research partnerships, which benefit from their diverse expertise in: a. Biological network modeling and analysis; c. Integrative, large-scale analysis of multi-omics data; and C. Biostatistics and machine learning.

Research projects

  • “Drug repositioning for the treatment of myocardial infarction through systems biology approaches (INFUSED)”, Luxembourg’s National Research Fund (FNR) / Swiss National Science Foundation (SNSF).
  • “Non-coding RNA regulatory circuits in glioma” (CIRCUITOMA), FNR, INTER programme.
  • “New tools for the prediction of influential nodes and links in multi-level cancer-related networks”, FNR, Luxembourg-Singapore cooperation programme, 2016-2018

Featured Publications

Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity.

  • Proteomics of cellular signaling
  • Neuro-Oncology Laboratory
  • Computational Biomedicine
February 19, 2020
2020 Feb. Sci Rep.10(1):2896.
By:
  • Rodius S
  • de Klein N
  • Jeanty C
  • Sanchez-Iranzo H
  • Crespo I
  • Ibberson M
  • Xenarios I
  • Dittmar G
  • Mercader N
  • Niclou SP
  • Azuaje F.

Standardization of the preanalytical phase of DNA extraction from fixed tissue for next-generation sequencing analyses.

  • Computational Biomedicine
January 25, 2020
2020 Jan. N Biotechnol.54:52-61. Epub 2019 Aug 6.
By:
  • Kofanova O
  • Bellora C
  • Garcia Frasquilho S
  • Antunes L
  • Hamot G
  • Mathay C
  • Mommaerts K
  • Muller A
  • DeWitt B
  • Betsou F.
See all publications

Contacts

Petr Nazarov

Ph.D.

1A-B, rue Thomas Edison
1445 Strassen
Luxembourg
Tel. : +352 26970-385