Activities

The work of the Allergy and Clinical Immunology group has its focus on the common pathways leading to activation of immune reactions and induction of immune tolerance in various diseases, with special attention on IgE-mediated allergies.

Our goals are to identify and characterize novel insect venom allergens (in collaboration with Helmholtz Center, Munich) and to perform clinical-translational studies on anaphylaxis to various allergens (in collaboration with Odense Research Centre in Anaphylaxis/ORCA, University of Southern Denmark), but also on tolerance responses developing in patients undergoing allergen-specific immunotherapy (in collaboration with Centre Hospitalier de Luxembourg/CHL, Luxembourg). New targets for immune interventions and biomarkers for precision medicine will be developed and tested in pre-clinical models.

State-of-the-art techniques such as proteomics, CyTOF or gene network analysis are at our disposal to perform the studies.

Research projects

  • Molecular and clinical-translational studies on anaphylaxis (peanut, insect venom, wheat and fish).
  • Clinical-translational studies in patient cohorts with allergen-specific immunotherapy to insect venom, peanut and grass or birch pollen.
  • Assessment of novel targets for immunotherapy and experimental validation in murine models of allergy and immunotherapy.
  • Identification of biomarkers predicting the risk and the outcome of allergic disease and allergen-specific immunotherapy.

Featured Publications

Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response.

  • Allergy and Clinical Immunology
  • Immune Systems Biology
February 09, 2021
2021 Feb. Immunity.54(2):291-307 e7. Epub 2021 Jan 14.
By:
  • Golebski K
  • Layhadi JA
  • Sahiner U
  • Steveling-Klein EH
  • Lenormand MM
  • Li RCY
  • Bal SM
  • Heesters BA
  • Vila-Nadal G
  • Hunewald O
  • Montamat G
  • He FQ
  • Ollert M
  • Fedina O
  • Lao-Araya M
  • Vijverberg SJH
  • Maitland-van der Zee AH
  • van Drunen CM
  • Fokkens WJ
  • Durham SR
  • Spits H
  • Shamji MH.

EAACI statement on the diagnosis, management and prevention of severe allergic reactions to COVID-19 vaccines.

  • Allergy and Clinical Immunology
January 16, 2021
2021 Jan. Allergy. Online ahead of print.
By:
  • Sokolowska M
  • Eiwegger T
  • Ollert M
  • Torres MJ
  • Barber D
  • Del Giacco S
  • Jutel M
  • Nadeau KC
  • Palomares O
  • Rabin RL
  • Riggioni C
  • Vieths S
  • Agache I
  • Shamji MH.
See all publications

Contacts

Markus Ollert

M.D.

29, rue Henri Koch
L-4354Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-829