Activities

The work of the Allergy and Clinical Immunology group has its focus on the common pathways leading to activation of immune reactions and induction of immune tolerance in various diseases, with special attention on IgE-mediated allergies.

Our goals are to identify and characterize novel insect venom allergens (in collaboration with Helmholtz Center, Munich) and to perform clinical-translational studies on anaphylaxis to various allergens (in collaboration with Odense Research Centre in Anaphylaxis/ORCA, University of Southern Denmark), but also on tolerance responses developing in patients undergoing allergen-specific immunotherapy (in collaboration with Centre Hospitalier de Luxembourg/CHL, Luxembourg). New targets for immune interventions and biomarkers for precision medicine will be developed and tested in pre-clinical models.

State-of-the-art techniques such as proteomics, CyTOF or gene network analysis are at our disposal to perform the studies.

Research projects

  • Molecular and clinical-translational studies on anaphylaxis (peanut, insect venom, wheat and fish).
  • Clinical-translational studies in patient cohorts with allergen-specific immunotherapy to insect venom, peanut and grass or birch pollen.
  • Assessment of novel targets for immunotherapy and experimental validation in murine models of allergy and immunotherapy.
  • Identification of biomarkers predicting the risk and the outcome of allergic disease and allergen-specific immunotherapy.

Featured Publications

Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic.

  • Allergy and Clinical Immunology
September 07, 2020
2020 Sep. Allergol Select.4(1):53-68.
By:
  • Klimek L
  • Pfaar O
  • Worm M
  • Eiwegger T
  • Hagemann J
  • Ollert M
  • Untersmayr E
  • Hoffmann-Sommergruber K
  • Vultaggio A
  • Agache I
  • Bavbek S
  • Bossios A
  • Casper I
  • Chan S
  • Chatzipetrou A
  • Vogelberg C
  • Firinu D
  • Kauppi P
  • Kolios A
  • Kothari A
  • Matucci A
  • Palomares O
  • Szépfalusi Z
  • Hötzenecker W
  • Rosenkranz AR
  • Bergmann KC
  • Bieber T
  • Buhl R
  • Buters J
  • Darsow U
  • Keil T
  • Kleine-Tebbe J
  • Lau S
  • Maurer M
  • Merk H
  • Mösges R
  • Saloga J
  • Staubach P
  • Jappe U
  • Rabe KF
  • Rabe U
  • Vogelmeier C
  • Biedermann T
  • Jung K
  • Schlenter W
  • Ring J
  • Chaker A
  • Wehrmann W
  • Becker S
  • Freudelsperger L
  • Mülleneisen N
  • Nemat K
  • Czech W
  • Wrede H
  • Brehler R
  • Fuchs T
  • Tomazic PV
  • Aberer W
  • Fink-Wagner AH
  • Horak F
  • Wöhrl S
  • Niederberger-Leppin V
  • Pali-Schöll I
  • Pohl W
  • Roller-Wirnsberger R
  • Spranger O
  • Valenta R
  • Akdis M
  • Matricardi PM
  • Spertini F
  • Khaltaev N
  • Michel JP
  • Nicod L
  • Schmid-Grendelmeier P
  • Idzko M
  • Hamelmann E
  • Jakob T
  • Werfel T
  • Wagenmann M
  • Taube C
  • Jensen-Jarolim E
  • Korn S
  • Hentges F
  • Schwarze J
  • L OM
  • Knol EF
  • Del Giacco S
  • Chivato Pérez T
  • Bousquet J
  • Bedbrook A
  • Zuberbier T
  • Akdis C
  • Jutel M.

Accelerated epigenetic aging as a risk factor for chronic obstructive pulmonary disease and decreased lung function in two prospective cohort studies.

  • Allergy and Clinical Immunology
August 03, 2020
2020 Aug. Aging.12(16):16539-16554. Epub 2020 Aug 3.
By:
  • Breen M
  • Nwanaji-Enwerem JC
  • Karrasch S
  • Flexeder C
  • Schulz H
  • Waldenberger M
  • Kunze S
  • Ollert M
  • Weidinger S
  • Colicino E
  • Gao X
  • Wang C
  • Shen J
  • Just AC
  • Vokonas P
  • Sparrow D
  • Hou L
  • Schwartz JD
  • Baccarelli AA
  • Peters A
  • Ward-Caviness CK.
See all publications

Contacts

Markus Ollert

M.D.

29, rue Henri Koch
L-4354Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-829