Post-Doctoral Fellow in Immune Ageing and Systems Immunology

PROJECT

This FNR CORE-funded project aims to advance fundamental knowledge in comprehending human T-cell differentiation mechanisms, i.e., by systematically identifying regulators promoting or inhibiting the CD8 T-cell subset differentiation process using large-scale CRISPR screening in primary human CD8 T cells. A focus will be put on the discovery of the molecular regulatory mechanisms modulating our recent-reported skewed CD8 differentiation in Parkinson’s disease. Among others, one of the objectives is to validate the candidate regulators in iPSC-differentiated neuron and T-cell co-culturing. The successful postdoc candidate will be embedded in a state-of-the-art laboratory at the Department of Infection and Immunity composed of ~100 staff members. This project will be performed in close cooperation with the labs of Prof. Rejko Krüger (Luxembourg) and Prof. Alfred Zippelius (Basel).

KEY SKILLS, EXPERIENCE AND QUALIFICATIONS

• Successful PhD (ideally PhD awarded within 2 years; or expect to defend before the agreed starting date) in the area of immunology or molecular or cellular biology;
• Expected to have: hands-on laboratory experience in large-scale CRISPR screening, ideally in T cells;
• Expected to have: laboratory experience in immune cell isolation, culture, differentiation and related molecular and cellular experiments;
• Expected to have: hands-on experience in cytometry and sorting experience;
• Good to have: skills in large-scale data analysis including single-cell RNA-seq analysis (in R or Python);
• Good to have: experience in iPSC and neurodegenerative diseases;
• Good to have: mice handling experience
• Self-driven, open-minded and curious person, willing to work in a competitive, interdisciplinary, cooperative and international environment.

For any further information please visit:

Dr. Feng Hefeng (PI of the project): https://orcid.org/0000-0003-2657-7361

Prof. Rejko Krüger: https://orcid.org/0000-0003-4258-6241

Prof. Alfred Zippelius: https://orcid.org/0000-0003-1933-8178

GENDER EQUALITY

The LIH is an equal opportunities employer. 

We are fully committed to removing any discriminatory barrier related to gender, and not only, in recruitment and career progression of our staff. 

The LIH is attentive to gender representation among its leadership staff and aims to eliminate obstacles to the recruitment and promotion of female leaders and their career development.

DEADLINE TO APPLY

Applications including a letter detailing your motivation and a curriculum vitae should be sent before April 15th. Applications will be screened before this deadline and the position will remain open until filled.