Activities

Beyond their role in preventing genetic instability and tumorigenesis, DNA repair and epigenetic mechanisms also contribute to the resistance of cancer cells to chemotherapeutic genotoxics. These mechanisms are responsible in great part for the failure of current anti-glioma therapies. Our research group is developing several approaches (including differential shRNA screens, multiplexed gene expression analyses and studies in xenograft animal models) to better understand the DNA repair and epigenetic factors that operate in glioblastoma and identify critical therapeutic targets to prevent chemoresistance.

A second line of investigation explores fundamental aspects of the mechanisms underlying centromere dynamics as well as heterochromatin expression in mammalian cells.

Close collaborators include Drs R. Golbrunner and M. Timmer (Uniklinik Köln), Drs F. Sholtes and D. Martin (CHU Liège) and Dr Y.G. Yang (Beijing Institute of Genomics).

Research projects

  • Identification of novel molecular targets for temozolomide-based therapies against glioblastoma: a comprehensive shRNA-based screen of DNA damage response factors.
  • Impact of DNA repair genes and associated miRNAs in GBM biology and resistance to temozolomide: study of TMZ-positive and TMZ-negative GBM cohorts.
  • Epigenetic factors mediating heat-shock-induced expression of heterochromatin in human cells.

Featured Publications

A DNA repair and cell cycle gene expression signature in pediatric high-grade gliomas: Prognostic and therapeutic value.

  • DNA Repair and Chemoresistance
  • Multiomics Data Science
May 07, 2021
2021 May. Cancers.13(9):2252.
By:
  • Entz-Werlé N
  • Poidevin L
  • Nazarov PV
  • Poch O
  • Lhermitte B
  • Chenard MP
  • Burckel H
  • Guérin E
  • Fuchs Q
  • Castel D
  • Noel G
  • Choulier L
  • Dontenwill M
  • Van Dyck E.

Temozolomide-induced RNA interactome uncovers novel lncRNA regulatory loops in glioblastoma.

  • NORLUX Neuro-Oncology Laboratory
  • Quantitative Biology Unit
  • DNA Repair and Chemoresistance
September 10, 2020
2020 Sep. Cancers.12(9).
By:
  • Fritah S
  • Muller A
  • Jiang W
  • Mitra R
  • Sarmini M
  • Dieterle M
  • Golebiewska A
  • Ye T
  • Van Dyck E
  • Herold-Mende C
  • Zhao Z
  • Azuaje F
  • Niclou SP.
See all publications

Contacts

Eric Van Dyck

Ph.D.

84, rue Val Fleuri
L-1526Luxembourg
Luxembourg
Tel. : +352 26970-239