Activities

The human gut microbiome plays key roles in health and disease. Although diet is a major driver of the microbiota physiology, the gut microbiota-mediated mechanisms that link diet to intestinal disorders and enteric infections are poorly understood. Our work is focused on discerning these mechanisms and underlying eco-immunological processes via colonic mucus barrier−gut microbiota interactions. Since the modern diet of developed countries  includes significantly reduced dietary fiber, we seek to understand how a fiber-deprived gut microbiota impacts human  health.

Collaborations

  • Prof. Eric Martens, University of Michigan, USA
  • Prof. Gabriel Nunez, University of Michigan, USA
  • Prof. Bruce R. Hamaker, Purdue University, USA

Research Projects

Using gnotobiotic mouse models containing fully characterized human gut bacterial communities, we inted to:

  • Study how a fiber-deprived gut microbiota resorts to host-secreted mucin glycoproteins leading to erosion of the colonic mucus barrier
  • Investigate host immune regulation in response to the fiber-deprived gut-microbiota-mediated erosion of the colonic mucus layer
  • Examine changes in host susceptibility to an intestinal pathogen (Citrobacter rodentium) during microbiota-mediated erosion of the colonic mucus layer
  • Design and test practicable prebiotic diets in order to maintain populations of fiber-degrading bacteria

Featured Publications

Gut Commensal-Induced IkappaBzeta Expression in Dendritic Cells Influences the Th17 Response.

  • Eco-Immunology and Microbiome
January 19, 2021
2021 Jan. Front Immunol.11:612336.
By:
  • Michaelis L
  • Tress M
  • Low HC
  • Klees J
  • Klameth C
  • Lange A
  • Griesshammer A
  • Schafer A
  • Menz S
  • Steimle A
  • Schulze-Osthoff K
  • Frick JS.
See all publications

Contacts

Mahesh Desai

Ph.D.

29, rue Henri Koch
L-4354Esch-sur-Alzette
Luxembourg
Tel. : +352 26970-389