Internship Position in Leukemia Research (Master students) - AL0124

BACKGROUND

Chronic  Lymphocytic Leukemia (CLL) represent the most frequent leukemia in  adults. Despite recent advances in treatments, CLL remains a deadly  incurable disease. This cancer is caracterized by an accumulation of  abnormal, apoptosis resistant, B lymphocytes in the blood and lymphoid  organs of the patients. CLL progression is highly dependent on complex  interactions between tumor cells and their microenvironment. Indeed, CLL  cells can modify stromal cells and immune cells to promote their  survival and to escape from the immune surveillance system.

OBJECTIVES

Our  team focuses on the mechanisms leading to leukemia progression, in  particular the influence of CLL cells on stromal cells and immune cells  located in their microenvironment, with the goal to identify new  prognostic markers and therapeutic targets.

TRAINING AND RESEARCH ENVIRONMENT

Tumor Stroma Interactions research group is a dynamic and  multinational team whose current members originate from France, Belgium,  Luxembourg, Spain, Germany, Italy and Argentina. It belongs to the Department of Cancer Research, whose research  activities focus on the cellular and molecular mechanisms of tumor  progression using a wide range of cutting edge technologies, including  genomic, transcriptomic and proteomic analyses, as well as in vitro and in vivo imaging  modalities using state-of-the art animal models for cancer research.  The post-doctoral researcher will be working on a large FNR CORE-funded  project that aims to explore the complex interplay between CLL cells and  immune cells in the microenvironment, and will be co-supervised by Dr.  E. Moussay (PI) and Dr. J. Paggetti (PI).

Recent related  references (open access): Gargiulo, E., Viry, E., Morande, P. E. et al.  Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL  Progression by Hampering Antitumor T-cell Responses. Blood Cancer Discov  4, 54-77 (2023). https://doi.org:10.1158/2643-3230.BCD-22-0029

HOW TO APPLY

Applications including a cover letter and a curriculum vitae should be sent through our website via the apply button below. Please apply ONLINE formally through this web page. Applications by email will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

GENDER EQUALITY

The LIH is an equal opportunities employer. We are fully committed to removing any discriminatory barrier related to gender, and not only, in recruitment and career progression of our staff. The LIH is attentive to gender representation among its leadership staff and aims to eliminate obstacles to the recruitment and promotion of female leaders and their career development.