LIH priority research topics

LIH aims to perform research that transcends the classical boundaries of individual diseases and that can be tangibly applied in the clinical practice to address unmet needs, thus positively affecting health outcomes for patients.

Novel diagnostic, curative and preventive approaches are developed in a multidisciplinary manner, leveraging on the Institute’s expertise ranging from ‘omic’ approaches to public health epidemiology, exposure measurement and digital health. This translational and transversal research strategy is accompanied by the increasing appreciation of the role of the immune system in determining the balance between health and disease, implying that immune-related disorders share common mechanisms of action. These considerations have led LIH to centre its research activities on four key priority areas – cancer, immunological disorders, neurodegenerative diseases and preventive medicine.

LIH has built up a strong expertise in selected cancer types, including brain cancer, haematological malignancies and gastro-intestinal cancers.

LIH also builds on ongoing work in allergy research to understand the early onset, impact of environmental factors and predisposition to diseases with a strong immunological component and apply these insights to additional chronic immunological illnesses.

In terms of neurodegeneration, LIH leverages on the expertise gained through the FNR-funded National Centre of Excellence in Research on Parkinson’s Disease (NCER-PD), in collaboration with the Luxembourg Centre for Systems Biomedicine (LCSB), to further investigate the role of the immune system and of the brain-body axis in the pathogenesis and progression of Parkinson’s Disease and Multiple Sclerosis.

Drawing on its expertise in epidemiology, human biomonitoring, sport medicine, nutrition and molecular biology, LIH aims to perform interdisciplinary research to identify environmental, lifestyle and behavioural factors affecting health, ultimately supporting disease prevention and improving population health.

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