Scientific Output

Publications

1. Association between use of psychotropic medication prior to SARS-COV-2 infection and trajectories of COVID-19 recovery: Findings from the prospective Predi-COVID cohort study

Aguayo GA, Fischer A, Elbeji A, Linn N, Ollert M, Fagherazzi G. Front Public Health . 2023 Mar 16;11:1055440.

doi: 10.3389/fpubh.2023.1055440. eCollection 2023.

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2. Altered infective competence of the human gut microbiome in COVID-19

De Nies L, Galata V, Despotovic M, Bhanu Busi S, Snoeck C, Delacour L, Martin-Gallausiaux C, Poornima Budagavi D, Laczny C, Habier J, Lupu P-C, Halder R, Fritz JV, Marques T, Sandt E, O’ Sullivan MP, Ghosh S, Satagopam V, CON-VINCE Consortium, Krüger R, Fagherazzi G, Ollert M, Hefeng FQ, May P, Wilmes P.

Microbiome. 2023 Mar 9;11(1):46. doi: 10.1186/s40168-023-01472-7.

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3. Long COVID Classification: Findings from a Clustering Analysis in the Predi-COVID Cohort Study.

Fischer A, Badier N, Zhang L, Elbéji A, Wilmes P, Oustric P, Benoy C, Ollert M, Fagherazzi G.

Int J Environ Res Public Health. 2022 Nov 30;19(23):16018. doi: 10.3390/ijerph192316018.

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4. Vocal biomarker predicts fatigue in people with COVID-19: results from the prospective Predi-COVID cohort study.

Elbéji A, Zhang L, Higa E, Fischer A, Despotovic V, Nazarov PV, Aguayo GA, Fagherazzi G.

BMJ Open . 2022 Nov 22;12(11):e062463. doi: 10.1136/bmjopen-2022-062463.

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5. Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality”.

Madè A, Greco S, Vausort M, Miliotis M, Schordan E, Baksi S, Zhang L, Baryshnikova E, Ranucci M, Cardani R, Fagherazzi G, Ollert M, Tastsoglou S, Vatsellas G, Hatzigeorgiou A, Firat H, Devaux Y, and Martelli F.

Sci Rep . 2022 Nov 21;12(1):20048. doi: 10.1038/s41598-022-23922-2

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6. Recommendations for Successful Implementation of the Use of Vocal Biomarkers for Remote Monitoring of COVID-19 and Long COVID in Clinical Practice and Research.

Fischer A, Elbeji A, Aguayo G, Fagherazzi G.

Interact J Med Res. 2022 Nov 15;11(2):e40655. doi: 10.2196/40655.

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7. Discovery and analytical validation of a vocal biomarker to monitor anosmia and ageusia in patients with COVID-19: Cross-sectional study.

Higa E, Zhang L, Elbéji A, Fischer Q, Aguayo GA, Nazarov PV, Fagherazzi G.

JMIR Med Inform 2022 Nov 8;10(11):e35622. doi: 10.2196/35622.

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8. A Voice-Based Biomarker for Monitoring Symptom Resolution in Adults with COVID-19: Findings from the Prospective Predi-COVID Cohort Study.

Fagherazzi G, Zhang L, Elbéj A,  Higa E, Despotovic V, Ollert M, Aguayo GA, Nazarov P, Fischer A.

PLOS Digital Health. 2022¸1(10): e0000112. 2022 Oct 20.

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9. Long COVID symptomatology after 12 months and its impact on quality of life according to initial COVID-19 disease severity.

Fischer A, Zhang L, Elbéji A, Wilmes P, Oustric P, Staub T, Nazarov PV, Ollert M, Fagherazzi G.

Open Forum Infectious Diseases, Volume 9, Issue 8, August 2022, ofac397, eCollection 2022 Aug.

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10. Associations between physical activity prior to infection and COVID-19 disease severity and symptoms: results from the prospective Predi-COVID cohort study.

Malisoux L, Backes A, Fischer A, Aguayo G, Ollert M, Fagherazzi G.

BMJ Open. 2022;12(4):e057863. 2022 Apr 29.

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11. Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients

Capelle C, Cire S, Domingues O, Ernens I, Hedin F, Fischer A, Snoeck C, Ammerlaan W, Konstantinou M, Grzyb K, Skupin A, Carty CL, Hilger C, Gilson G, Celebic A, Del Sol A, Kaplan IM, Betsou F, Abdelrahman T, Cosma A, Vaillant M, Fagherazzi G, Ollert M, Hefeng FQ.

Cell Rep Med. 2022 Mar 29;2(4):100600

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12. Detection of COVID-19 from voice, cough and breathing patterns: Dataset and preliminary results.

Despotovic V, Ismael M, Cornil M, Call RM, Fagherazzi G.

Comput Biol Med. 2021 Nov;138:104944. doi: 10.1016/j.compbiomed.2021.104944. Epub 2021 Oct 13.

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13. An antigen microarray protocol for COVID-19 serological analysis.

Longworth J, Dittmar G.

STAR Protoc. 2021 Sep 17;2(3):100815. doi: 10.1016/j.xpro.2021.100815. Epub 2021 Aug 26.

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14. Protocol for a prospective, longitudinal cohort of people with COVID-19 and their household members to study factors associated with disease severity: the Predi-COVID study.

Fagherazzi G, Fischer A, Betsou F, Vaillant M, Ernens I, Masi S, Mossong J, Staub T, Brault D, Bahlawane C, Rashid MA, Ollert M, Gantenbein M, Huiart L.

BMJ Open. 2020 Nov 23;10(11):e041834,

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15. Digital Health Strategies to Fight COVID-19 Worldwide: Challenges, Recommendations, and a Call for Papers

Fagherazzi G, Goetzinger G, Rashid MA, Aguayo GA, Huiart L.

J Med Internet Res. 2020 Jun; 22(6): e19284.

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Sub-studies and Programmes: 12 ancillary studies and 1 research programme

Nine projects funded by the FNR Covid-19 Fast track call:

• Co-Infectomics (Paul Wilmes, University of Luxembourg) : Multi-omics evaluation of microbial co-infection as marker of COVID-19 severity
• CoronaStep + (Chantal Snoeck, LIH /Leslie Ozorgaly LIST): The value of sewage surveillance to provide new insights on the circulation of SARSCoV-2 and to reveal the true extent of the coronavirus pandemic at the national scale
• CoV-Array (Joseph Longworth, LIH) : Rapid serological profiling of SARS-CoV-2 antibody response
• Funbiome (Mahesh Desai, LIH/Paul Wilmes (UL): Functional characterization of Covid-19 patient gut microbiome
• HorCovIS (Brice Appenzeller, LIH): Hormonal status as predictor of Covid-19 infection severity
• miRCOVID (Yvan Devaux, LIH): MicroRNA biomarkers of COVID-19 severity
• RAS CoV-2 (Antonio Cosma, LIH): Peptide / protein / single-cell map of the renin-angiotensin system in Covid-19 (RAS CoV-2)
• CovSerum (Gunnar Dittmar, LIH/Iris Behrman (UL): Early detection of COVID19-induced tissue damage and (hyper)inflammation from serum samples
• CDCVA (Dr Muhannad Ismael (LIST): COVID-19 Detection by Cough and Voice analysis

Two H2020 projects on Covid-19 using Predi-COVID data/samples

• COVIRNA (LIH as Consortium Coordinator, PI: Yvan Devaux): A diagnostic test to improve surveillance and care of Covid-19 patients
• unCoVer (LIH: Michel Vaillant): Unravelling data for rapid evidence-based response to COVID-19

One Luxinnovation PPP HealthTech call –  FNR & MECO (2023-2025)

• DigiCog (Magali Perquin LIH): Monitoring “long-COVID” impact on cognition via digital neuropsychological assessment

One Research Programme – Ministry of Health & High Commission for National Protection (HCPN) (2021-2024)

• CoVaLux (Paul Wilmes/Guy Fagherazzi (LIH)): COVID-19, vaccination and longer-term health consequences of COVID-19 in Luxembourg