About the Study

The ImmunoGal study, in partnership with the Ministry of Health and Social Security, will explore the early immune responses triggered by tick bites, with a focus on α-Gal syndrome, a red meat allergy linked to tick exposure. Adults who have recently been bitten by a tick will be recruited and assessed at two time points, immediately after the bite and again 4-6 weeks later.

This study aims to enhance understanding of α-Gal syndrome and contribute to improved diagnosis and prevention strategies.

What happens when you contact us?

Our research team will check if you are eligible to participate.

If so, we will explain everything about the study process and if you agree, you will be invited to meet with us for an assessment.

Meet us again for another assessment 4-6 weeks later. A subgroup will be selected for a 3rd visit up to 3 months after the first visit.

Send an email

immunogal@lih.lu

Give us a call

+352 26 970-400

What will the ImmunoGal study consist of?

  • Identification of tick species involved;
  • Detection of potential pathogens transmitted by ticks;
  • Assessment of immediate and late immune responses in participants;
  • Evaluation of allergic sensitisation following tick bites.

The impact of your participation

Your participation will allow researchers to generate data and answer questions like:

  • When and where do ticks bite people?
  • Which kind of ticks (species and developmental stage) are biting humans?
  • What percentage of ticks that bite people are infected with pathogens?

This information will help a great deal because our current understanding of tick bites is quite limited. Therefore, the ImmunoGal study will collect the relevant data on a nationwide level in Luxembourg to better understand the current situation.

By participating and donating your blood for this study, you will help us determine:

  • How the human immune system defends itself against ticks and tick parasites,
  • How the human immune system fights transmission of tick parasites to humans,
  • Why these defence mechanisms sometimes deviate into allergic reactions such as the α-Gal syndrome.

Finding the answers to these questions will improve tick bite prevention and help refine how we diagnose and treat tick-borne diseases.

Contact Details

Molecular and Translational Allergology

+352 26970-400

immunogal@lih.lu

Partners

FAQs

What are ticks?

Ticks are parasitic arachnids (not insects). Ticks may vary in size at different life stages: the larva is about 0.5 mm, the nymph is 1-2 mm, and the adult can range from 3 to 5 mm, growing larger after feeding.  They normally feed on blood of animals such as small mammals, birds, or deer. They ‘bite’ by piercing the host skin with a special mouthpart.

Occasionally, they can also feed on humans. The bite itself is not painful, nor harmful and often goes unnoticed. However, ticks can transmit pathogens to their host during their blood meal, or even trigger a food allergy to mammalian meat, which are the actual threats of a tick bite for humans.

Where are ticks commonly found?

Ticks can be found in principally any green area, like parks, gardens, meadows, forests, etc. They linger in high grass, bushes or forest litter, waiting for a host to pass by. They do not jump or fall from trees!

When is tick season?

Ticks are hibernating during winter. They are active from early spring to late autumn.

How can I prevent tick bites?

The most effective protection against tick bites is adequate clothing: closed shoes, long sleeves, and long trousers tucked into socks or boots. While hiking, stay on the trails, where the risk of tick bites is lower, since ticks prefer dense vegetation. Choose preferably light colors for the clothing), so you can actually spot a tick better. Repellents, such as permethrin-containing insecticide, can be used to treat socks and trouser legs.

How do I properly remove a tick?

After every outdoor activity, it is important to do a body scan and remove any tick as soon as possible. The best way to remove a tick is grasping it as close to the skin’s surface as possible and pulling it out slowly and steadily without twisting. One can use a removal device available in pharmacies or any fine-tipped forceps.. Do not apply any substances, such as alcohol or Vaseline, while the tick is still attached, because this might induce the tick to regurgitate its gut content into the bite wound and increase the risk of infection. After removing the tick, you can clean the bite site with disinfectant.

I’m interested in participating in the study, what should I do?

Remove the tick that has bitten you as soon as possible, or seek medical assistance for the tick removal at your general practioner, “Maison Médicale” or emergency room. Keep the tick (in a small plastic/glass container or well-sealed envelope) and contact the study team to make an appointment within 48 hours (tel. +352 26 970-400). They will further guide you through the process and answer all your questions. Alternatively, you can contact the study team and have your tick removed at your appointment.

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