Home » News » Department of Infection and Immunity triumphs at EAACI
Department of Infection and Immunity triumphs at EAACI
LIH scientists were elected to international scientific leadership boards and presented their research to more than 7000 participants at the Annual Congress of the European Academy of Allergy and Clinical Immunology.
Luxembourg Institute of Health (LIH) scientists were strongly represented at this year’s Annual Congress of the European Academy of Allergy and Clinical Immunology (EAACI) to communicate their successful projects in allergy research conducted in Luxembourg. Five young researchers presented their latest research related to allergic disease mechanisms, allergo-oncology and microbiome. Starting term of office at the 2022 EAACI-Congress in Prague, four LIH scientists were elected as leading experts to EAACI boards for the duration of two years.
The annual EAACI congress is the world’s largest congress specialising in the field of allergy and clinical immunology, gathering scientists and clinicians from all across the globe to exchange their data and views on the latest scientific and medical advancements . This year, the congress was held in hybrid mode, with more than 4,216 on-site and 2,837 online participants in Prague, Czech Republic, from 1st to 3rd of July 2022.
Both Group Leaders of the Molecular & Translational Allergology Group at the LIH-Department of Infection and Immunity (DII) were very successful in this year’s EAACI board elections. Dr. Christiane Hilger was elected as Chair of the EAACI Interest Group on ‘Allergy Diagnosis & Systems Medicine’ , while Dr. Annette Kuehn received a mandate from the electorate as board member of the same interest group for the period of 2022-2024. Dr Hilger was also part of the Scientific Programme Committee of the 2022 EAACI-Congress. She gave an invited lecture on ‘Allergy to furry animals: different sensitization patterns and their interpretation’. Dr. Hilger’s team is actively engaged in advancing precision-based allergy laboratory diagnosis and in the investigation of mechanisms leading to disruption of the epithelial barrier in respiratory and food allergy diseases.
Prof. Markus Ollert, Director of LIH-DII and Group Leader of the Allergy and Clinical Immunology research group at DII, was newly elected as EAACI Vice President Science for the term 2022-2024, during which he will be part of the Board of Officers and the Executive Committee of EAACI (link: https://www.eaaci.org/organisation/leadership.html ). In his role, he will help to continue EAACI’s successful journey to provide the leading platform for education and science in the field for its more than 13,000 members, thus supporting doctors and researchers with the best practices and tools to facilitate standardised, high-quality care and translational research in allergy, asthma and clinical immunology.
Neera Chakrapani, PhD student in the group of Dr. Hilger, was awarded a travel grant to present her research in Prague. She gave a short oral presentation on ‘Mouse blood protein survives degradation in Ixodes ricinus ticks after molting and upon starvation up to 6 months’, providing evidence that ticks can store blood proteins from an animal on which they fed, for a very long time. These animal proteins from ticks are likely allergen sources for triggering allergy to red meat, a disease now recognized worldwide as a non-infectious tick (vector)-borne disease.
Rebecca Czolk, Dr. Kuehn’s PhD student, introduced her research entitled ‘The microbial composition of the gut microbiome varies between peanut-allergic children and healthy controls’. She described differences of the human gut microbiome between peanut-allergic children and healthy controls, showing how bacterial strains associated with known opportunistic infections were overrepresented in allergic patients. This points to hitherto unknown patterns of dysbiosis and putative novel targets for modulation of type-2 immunity via the gut microbiome
Agnieszka Demczuk, PhD student in Prof. Ollert’s group, reported on latest insights of her research entitled ‘Low-level non-inflammatory activation of the IL-6/IL-6 receptor pathway characterizes the early immune signature of successful allergen-specific immunotherapy’. She presented data from patients undergoing clinically successful insect venom immunotherapy, the resulting immune signatures in patients and their validation in a preclinical mouse model, resulting in important mechanistic links for early patient stratification and biomarker use for clinical response.
Dr. Marie Boudaud, post-doctoral fellow in the group of Prof. Mahesh Desai, gave a short oral presentation entitled ‘A mucin-degrading gut bacterium modulates food allergy sensitization in a diet-dependent manner’. Although alterations in the gut microbiome, including diet-driven changes, are commonly linked to the rising prevalence of food allergy, little is known about mechanisms of how gut bacteria are involved in the breakdown of oral tolerance. Dr. Boudaud reported that Akkermansia muciniphila, a commensal mucin-degrading gut bacterium, mediates the dietary fiber deprivation-induced exacerbation of anaphylaxis symptoms in an allergic mouse model, by promoting a colonic type-2 immune response. These results reveal important and so far unknown diet-dependent effects of A. muciniphila in the pathogenesis of food allergy.
Dr. Aurélie Poli, scientist in the Neuro-Immunology Group of the LIH-Department of Cancer Research and elected board member of the EAACI Working Group AllergoOncology, gave a lecture entitled “The impact of allergic inflammation in cancer risk and progression” during the symposium dedicated to “The role of IgE in AllergoOncology, from allergy inducer to cancer killer”. During her talk, Dr. Poli defined the concept of AllergoOncology and highlighted how allergic inflammation can potentiate cancer immune surveillance and favor tumor elimination. She then presented her unpublished work regarding the impact of allergic inflammation on glioblastoma risk and progression, a project that aims to elucidate the underlying immunological factors involved in the inverse association between allergic inflammation and glioma.
FNR-CORE, FNR-PRIDE, Action LIONS “Vaincre le Cancer”, EAACI.
Markus OllertDirector of Department of Infection and Immunity
Group Leader of the Allergy and Clinical Immunology research group
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
5 months 27 days
This cookie is set by the Google recaptcha service to identify bots to protect the website against malicious spam attacks.
Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Advertisement" category .
Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Analytics" category .
The cookie is set by the GDPR Cookie Consent plugin to record the user consent for the cookies in the category "Functional".
Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Necessary" category .
Set by the GDPR Cookie Consent plugin, this cookie is used to store the user consent for cookies in the category "Others".
Set by the GDPR Cookie Consent plugin, this cookie is used to store the user consent for cookies in the category "Performance".
This cookie is native to PHP applications. The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website. The cookie is a session cookies and is deleted when all the browser windows are closed.
Analytical cookies are used to understand how visitors interact with the website. These cookies provide information on metrics such as number of visitors, bounce rate, traffic source, etc.
The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors.
This cookie is installed by Google Analytics.
Set by Google to distinguish users.
Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously.
YouTube sets this cookie via embedded youtube-videos and registers anonymous statistical data.