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🇬🇧 Modelling Neuroinflammation using iPS cells

02/07/2024 14:00 an 16:00

Bitte beachten Sie, dass der Inhalt nur auf Englisch verfĂĽgbar ist.

Speakers

Dr Sally
Cowley

Head, James and Lillian Martin Centre for Stem Cell Research
Sir William Dunn School of Pathology University of Oxford

Microglia are increasingly implicated in neurodegenerative disease, for example in Alzheimer’s numerous disease-associated genes are expressed predominantly in microglia/macrophage lineages. We have previously pioneered protocols for the efficient differentiation of macrophages from human induced Pluripotent Stem Cells, and have adapted these protocols for modelling the brain-resident cousins of macrophages, microglia. iPS-cell microglia can be produced at scale, and as terminally differentiated, karyotypically normal cells with an authentic phenotype that faithfully recapitulate the genetic background of the donor, are well suited for examining the role of neurodegenerative disease-associated genes in microglia. We are using these iPS-cell models to examine the role of neurodegenerative disease-associated genes in microglia, especially in relation to inflammatory pathways, the uptake of dying neurons, and processing of the aggregation-prone protein tau.


Host
Rejko
KrĂĽger

LOCATION

Chalet room
Sporthotel Lew eck

1 LĂ«pschter Dellt
L-9378 Lipperscheid, Lux

Event number: 2731 706 7300
Event password: MPn3mhfiD43
(67636434 when dialing from a phone or video system)

REGISTRATION

*On-site registration, please drop an
email to bianca.dragomir@lih.lu

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