Neurodegenerative diseases

Leveraging on the expertise gained through the FNR-funded National Centre of Excellence in Research on Parkinson’s Disease (NCER-PD), and in collaboration with the Luxembourg Centre for Systems Biomedicine (LCSB), LIH investigates the role of the immune system in the pathogenesis and progression of neurodegenerative disorders like Parkinson’s Disease.

The complexity of immune-mediated diseases of the central nervous system, like Parkinson’s Disease (PD) and Multiple Sclerosis (MS), their challenging management and increasing incidence emphasise the importance of a gaining deeper understanding of the roles of the immune system and of the brain-body axis in the genesis of such pathologies.

Ongoing projects in this respect include the comparison of the peripheral immune systems of PD patients and healthy controls and the elucidation of a correlation with disease development.

The NCER-PD approach is also being transposed to other neurodegenerative disorders, namely Multiple Sclerosis (MS), with the aim of setting up a national cohort of patients with MS. While an autoimmune origin has been established for MS, no effective cure or prevention is currently available.

LIH research groups

Several LIH research groups are currently working on this highly transversal priority area, integrating a broad set of in-house methodologies and capacities — ranging from ‘-omic’ approaches to epidemiology, exposure measurement and digital health expertise — thus studying the disease from different angles in a truly holistic way.

Discover the different research groups below.