Activities

Hypoxic stress in the tumor microenvironment is associated with tumor resistance to anti-cancer therapies. Hypoxia has been reported to play a key role in shielding tumour cells from immune cell attack either by promoting immune suppression, or by inducing many other oncogenic events and/or resistance mechanism (e.g. autophagy) in cancer cells, allowing tumour to escape from immune cell attack. We are interested in studying the molecular mechanism by which hypoxia allows cancer cells escape from immune surveillance and to investigate how targeting autophagy could improve cancer immunotherapy by switching the tumor microenvironment from immunosuppressive to immunopermissive for cytotoxic immune cells. Our collaboration with Gustave Roussy Cancer Center (France) allows us to conduct research at the interface between fundamental and clinically-oriented research programs.

Research projects

  • Effect of targeting hypoxia-induced autophagy in the improvement of the anti-tumour immune response in vivo.
  • Investigation of the autophagy-dependent mechanism involved in the regulation of tumour cell susceptibility to immune cell-mediated killing under hypoxic stress.
  • Study of the temporal dynamic of immune cells infiltrating autophagy competent or defective hypoxic tumours.

Featured Publications

Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints.

  • Tumor Immunotherapy and Microenvironment
August 28, 2019
2019 Aug. Cancer Lett.458:13-20. Epub 2019 May 25.
By:
  • Lequeux A
  • Noman MZ
  • Xiao M
  • Sauvage D
  • Van Moer K
  • Viry E
  • Bocci I
  • Hasmim M
  • Bosseler M
  • Berchem G
  • Janji B.

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment.

  • Immuno-Pharmacology and Interactomics
  • Tumor Immunotherapy and Microenvironment
  • Neuro-Oncology Laboratory
June 18, 2019
2019 Jun. Cells.8(6).
By:
  • Reynders N
  • Abboud D
  • Baragli A
  • Noman MZ
  • Rogister B
  • Niclou SP
  • Heveker N
  • Janji B
  • Hanson J
  • Szpakowska M
  • Chevigne A.
See all publications

Contacts

Bassam Janji

HDR, Ph.D.

84, rue Val Fleuri
L-1526 Luxembourg
Luxembourg
Tel. : +352 26970-285