Hypoxic stress in the tumor microenvironment is associated with tumor resistance to anti-cancer therapies. Hypoxia has been reported to play a key role in shielding tumour cells from immune cell attack either by promoting immune suppression, or by inducing many other oncogenic events and/or resistance mechanism (e.g. autophagy) in cancer cells, allowing tumour to escape from immune cell attack. We are interested in studying the molecular mechanism by which hypoxia allows cancer cells escape from immune surveillance and to investigate how targeting autophagy could improve cancer immunotherapy by switching the tumor microenvironment from immunosuppressive to immunopermissive for cytotoxic immune cells. Our collaboration with Gustave Roussy Cancer Center (France) allows us to conduct research at the interface between fundamental and clinically-oriented research programs.

Research projects

  • Effect of targeting hypoxia-induced autophagy in the improvement of the anti-tumour immune response in vivo.
  • Investigation of the autophagy-dependent mechanism involved in the regulation of tumour cell susceptibility to immune cell-mediated killing under hypoxic stress.
  • Study of the temporal dynamic of immune cells infiltrating autophagy competent or defective hypoxic tumours.

Featured Publications

Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy.

  • Tumor Immunotherapy and Microenvironment
June 21, 2021
2021 Jun. Oncogene. Online ahead of print.
  • Lequeux A
  • Noman MZ
  • Xiao M
  • Van Moer K
  • Hasmim M
  • Benoit A
  • Bosseler M
  • Viry E
  • Arakelian T
  • Berchem G
  • Chouaib S
  • Janji B.

Epithelial to mesenchymal transition regulates surface PD-L1 via CMTM6 and CMTM7 induction in breast cancer.

  • Tumor Immunotherapy and Microenvironment
March 09, 2021
2021 Mar. Cancers.13(5):1165.
  • Xiao M
  • Hasmim M
  • Lequeux A
  • Moer KV
  • Tan TZ
  • Gilles C
  • Hollier BG
  • Thiery JP
  • Berchem G
  • Janji B
  • Noman MZ.
See all publications


Bassam Janji

HDR, Ph.D.

84, rue Val Fleuri
Tel. : +352 26970-285