• NORLUX Neuro-Oncology Laboratory

LIH and ICM teams have played a key role in an international collaboration that resulted in two recent publications in Nature Genetics. These studies, conducted by the CARE consortium, uncover how glioblastoma tumor cell states co-evolve with their surrounding tumor microenvironment, giving rise to heterogeneous and complex cellular niches.

By analyzing matched primary and recurrent tumors at the single-cell level, the team demonstrated that the molecular evolution of tumor cells upon recurrence is closely linked to histopathological changes and the dynamic composition of microenvironmental niches.

This breakthrough was made possible through extensive international collaboration and access to unique patient cohorts, including LIH’s PRECISION-PDX study (www.precision-pdx.lu) and ICM’s Brain tumor biobank.

Read the full publications:
🔗 Study 1 – Nature Genetics: https://www.nature.com/articles/s41588-025-02167-5
🔗 Study 2 – Nature Genetics: https://www.nature.com/articles/s41588-025-02168-4