Parkinson’s disease
Leveraging the expertise gained through the FNR-funded National Centre of Excellence in Research on Parkinson’s Disease (NCER-PD), and in collaboration with the Luxembourg Centre for Systems Biomedicine (LCSB), LIH investigates the role of the immune system in the pathogenesis and progression of neurodegenerative disorders like Parkinson’s Disease.
activities
The complexity of immune-mediated diseases of the central nervous system, like Parkinson’s Disease (PD), their challenging management and increasing incidence, emphasise the importance of a gaining deeper understanding of the roles of the immune system and of the brain-body axis in the genesis of such pathologies.
Ongoing projects in this respect include the comparison of the peripheral immune systems of PD patients and healthy controls and the elucidation of a correlation with disease development.
Projects & clinical trials
Scientific publications
-
FGFR3 overexpression is a useful detection tool for FGFR3 fusions and sequence variations in glioma – 01/04/2021
-
Microglia in Health and Disease – 31/03/2021
-
Single-cell transcriptomics and In situ morphological analyses reveal microglia heterogeneity across the nigrostriatal pathway – 29/03/2021
-
PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons – 23/03/2021
-
Peripheral decarboxylase inhibitors paradoxically induce aromatic L-amino acid decarboxylase – 19/03/2021
-
Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons – 01/03/2021
-
A New Synuclein-Transgenic Mouse Model for Early Parkinson’s Reveals Molecular Features of Preclinical Disease – 01/02/2021
-
Quantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain as a novel regulator of striatal axonal branching in mice – 01/01/2021
-
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology – 01/12/2020
-
Cetuximab-mediated protection from hypoxia-induced cell death – 01/10/2020
