THE HIV-CLINICAL AND TRANSLATIONAL RESEARCH GROUP
The HIV Clinical and Translational Research (HIV-CTR) Group focuses on clinically oriented research in the field of HIV, hepatitis and SARS-COV-2 and provides new translational knowledge in immunology.
ACTIVITIES
The HIV Clinical and Translational Research (HIV-CTR) Group emerged from the Reference Laboratory of Retrovirology offering specialised technical support for the clinical follow-up of HIV and HCV-infected patients in Luxembourg since 1990. The group joined the Department of Infection and Immunity under the direction of Dr Carole Seguin-Devaux, and lead HIV clinical research in the field of resistance to antiviral therapy, transmission, molecular epidemiology and HIV Cure since 2014.
The HIV-CTR research team:
- Provides new translational knowledge on HIV cure and in immunology.
- Develop immunotherapeutic complexes boosting complement or NK cells activation against viruses, bacteria or cancer cells for further elimination by the immune system.
- Since the beginning of the COVID-19 epidemic, the group has developed SARS-CoV-2 cultures and HIV-pseudotypes/viral neutralisation assays for SARS-CoV-2 to assess the potency of antivirals and neutralising antibodies, respectively.
The Group is a partner in several European HIV and HCV networks, collaborates with lifescience and biotech companies, and has built up a network in Sub-Saharian African countries to support knowledge and technology transfer for the clinical management of HIV and hepatitis-infected patients.
Collaborations:
- European Society for Translational Antiviral Research (ESAR) and the Hepvir working group for hepatitis B and C
- EURESIST
- Breach HIV Cure consortium
- the Monod consortium for the clinical trial NCT01127204, evaluation of simplified antiretroviral treatment strategies in HIV infected children treated by antiretroviral before one year of age
- the COST action CM1407, NatChemdrugs
Seguin-Devaux
Projects & clinical trials
Featured team members
Scientific publications
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Direct-acting antiviral therapies for hepatitis C infection – 01/04/2024
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Flow cytometry conjugate formation assay between natural killer cells and their target cells – 11/03/2024
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HIV and people who inject drugs – 01/01/2024
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Prevalence of chronic HCV infection in EU/EEA countries in 2019 using multiparameter evidence synthesis – 01/01/2024
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The Role of Late Presenters in HIV-1 Transmission Clusters in Europe – 13/12/2023
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Multimeric immunotherapeutic complexes activating natural killer cells towards HIV-1 cure – 07/11/2023
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Incarceration history is associated with HIV infection among community-recruited people who inject drugs in Europe – 03/08/2023
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Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern – 06/10/2023
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Global prevalence, cascade of care, and prophylaxis coverage of hepatitis B in 2022 – 27/07/2023
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Multifunctional Heteromultimeric Constructs – 27/04/2023
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