bioinformatics (bioinfo) platform
The Bioinformatics Platform provides top of the line bioinformatics services to the research groups of the LIH and other collaborating partners.
activities
The Bioinformatics platform focuses on analysis centered around multi-omics data, their integration, statistical analysis, developing predictive models and presentation of the results in relevant figures. When needed, additional clinical data are considered and integrated with multi-omics data. The Bioinformatics platform also provides training in a variety of disciplines: biostatistics, R programming, data science, transcriptomics data analysis and machine learning.
HEAD OF UNIT
PETR
NAZAROV
NAZAROV
Projects & clinical trials
The group members contributed to the following research projects at LIH in the past two years:
- “A diagnostic test to improve surveillance and care of COVID-19 patients” (COVIRNA), EU Horizon 2020 Research and Innovation Programme, 2020-2023.
- “Glioma longitudinal analysis in Luxembourg: ex vivo and in vivo functional profiling of recurrent gliomas” (GLASS-LUX), FNR, 2021-2024.
- “Predicting the severity of COVID-19 infection” (Predi-COVID), FNR, Andre Losch Foundation, Luxembourg Institute of Health, The Government of Luxembourg.
- “Decomposition of mixed transcriptomes for classification of heterogeneous tumour samples (DEMICS)”, Luxembourg’s National Research Fund (FNR), 2018-2020.
- “Peptide, protein, single-cell map of the renin-angiotensin system in Covid-19” (RAS CoV-2), FNR Fast Track program, 2020
Featured team members
Scientific publications
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Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 02/04/2024
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Glioma subtype classification from histopathological images using in-domain and out-of-domain transfer learning – 15/03/2024
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Early-life influenza A (H1N1) infection independently programs brain connectivity, HPA AXIS and tissue-specific gene expression profiles – 11/03/2024
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Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy – 22/02/2024
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PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation – 09/02/2024
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AllergoOncology – 01/01/2024
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Audio- and Video-based Human Activity Recognition Systems in Healthcare – 01/01/2024
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Glioblastoma-instructed microglia transit to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts – 12/12/2023
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Inhibition of MIR-146A-5P decreases progression of melanoma brain metastasis via notch pathway dysregulation in astrocytes – 10/11/2023
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Targeting the dna damage response in glioblastoma propagating cells: from molecular mechanisms to precision medicine – 10/11/2023