ORISCAV-LUX

ORISCAV-LUX (Observation des Risques et de la Santé Cardio-Vasculaire au Luxembourg = Observation of Cardiovascular Risks and Health in Luxembourg) was the first nationwide epidemiological study aimed at establishing an objective picture of the prevalence of lifestyle-related risk factors for cardiovascular disease in the general population residing in the Grand Duchy of Luxembourg. The study made it possible to conduct epidemiologic research and describe major traditional and emerging cardiovascular risk factors and associated conditions, such as diabetes, hypertension, lipid disorders and their evolution between 2008 and 2018. The ORISCAV-LUX project was designed as a public health tool enabling epidemiologic research in Luxembourg and providing the authorities with reliable statistics on the health of the population residing in Luxembourg, in order to determine the prevention program best suited to actual needs.

The ORISCAV-LUX study was carried out by the Luxembourg Institute of Health (LIH) within the Department of Precision Health in 2007–2009 (Wave 1, 1432 participants) and in 2016-2018 (Wave 2, 1558 participants. It was co-financed by the Luxembourg Ministry of Health and the Luxembourg Ministry of Research.

Two waves of ORISCAV-LUX

Wave 1

November 2007 to January 2009
1 432 participants
18-65 years

Wave 2

January 2016 to February 2018
1 558 participants
25-80 years

Principal Investigators

Dr. Laurent
Malisoux

Profile

Dr. GUY
FAGHERAZZI

Profile

Collaborations

The ORISCAV Team is open to develop collaborative research studies on ORISCAV-LUX with other research institutions. Interested researchers can contact the principal investigators with their research ideas.

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Publications

Status 21.07.2025

  • Tharrey M, Klein O, Bohn T, Bulaev D, Van Beek J, Malisoux L, Perchoux C. Neighbourhood exposure to fast-food and sit-down restaurants and estimated 24-hour urinary sodium excretion: a cross-sectional analysis of urban adults from the ORISCAV-LUX 2 study. Public Health Nutr; 2025 28(1):e94 https://pubmed.ncbi.nlm.nih.gov/40257127/
  • Collaboration, NCD Risk  Collaborators from LIH: Fagherazzi G, Le Coroller G, Ruiz-Castell M).  General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7.5 million participants. Lancet; 2024 404(10467):2077-2093. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01405-3/fulltext
  • Backes A, Collings PJ, Portugal B, Quintero LC, Vahid F, Le Coroller G, Malisoux L,ORISCAV-LUX Study Group. Associations of movement behaviours and dietary intake with arterial stiffness: results from the ORISCAV-LUX 2 cross-sectional study. BMJ Open. 2024;14(7):e084933.  https://pubmed.ncbi.nlm.nih.gov/39067878/ 
  • Bouayed J, Vahid F. Carotenoid pattern intake and relation to metabolic status, risk and syndrome, and its components – divergent findings from the ORISCAV-LUX-2 survey. Br J Nutr. 2024; 14;132(1):50-66. https://pubmed.ncbi.nlm.nih.gov/38639131/
  • Van Beek JFE, Malisoux L, Klein O, Bohn T, Tharrey M, Van Lenthe FJ, Beenackers MA, Dijst M, Perchoux C. Longitudinal study of changes in greenness exposure, physical activity and sedentary behavior in the ORISCAV-LUX cohort study. Int J Health Geogr. 2024; 21;23(1):14.  https://pubmed.ncbi.nlm.nih.gov/38773577/
  • Tharrey M, Bohn T, Klein O, Bulaev D, Van Beek J, Nazare JA, Franco M, Malisoux L, Perchoux C. Local retail food environment exposure and diet quality in rural and urban adults: A longitudinal analysis of the ORISCAV-LUX cohort study. Health Place. 2024; 87:103240. https://pubmed.ncbi.nlm.nih.gov/38593577/
  • Tharrey M, Malisoux L, Klein O, Bohn T, Perchoux C. Urban densification over 9 years and change in the metabolic syndrome: A nationwide investigation from the ORISCAV-LUX cohort study. Soc Sci Med. 2023; 331:116002. https://pubmed.ncbi.nlm.nih.gov/37478660/
  • NCD Risk Factor Collaboration (NCD-RisC) Collaborators from LIH: Alkerwi A, Le Coroller G, Ruiz-Castell M).  . Diminishing benefits of urban living for children and adolescents’ growth and development. Nature. 2023; 615: 874-883. IF: 69.504 (2021). https://www-nature-com.proxy.bnl.lu/articles/s41586-023-05772-8
  • Tharrey, M., O. Klein, T. Bohn, L. Malisoux, and C. Perchoux. Nine-year exposure to residential greenness and the risk of metabolic syndrome among Luxembourgish adults: A longitudinal analysis of the ORISCAV-Lux cohort study. Health & Place. 2023; 81: 103020. IF: 4.81 (2021)- https://www.sciencedirect.com/science/article/pii/S1353829223000576
  • Vahid, F., A. Hoge, J. R. Hebert, T. Bohn, and Oriscav working group*. Association of diet quality indices with serum and metabolic biomarkers in participants of the ORISCAV-LUX-2 study. Eur J Nutr. 2023. IF: 4.74 (2021). https://link.springer.com/article/10.1007/s00394-023-03095-y
  • Collings, P. J., A. Backes, G. A. Aguayo, G. Fagherazzi, L. Malisoux, and Oriscav-Lux study group. Substituting device-measured sedentary time with alternative 24-hour movement behaviours: compositional associations with adiposity and cardiometabolic risk in the ORISCAV-LUX 2 study. Diabetol Metab Syndr. 2023; 15:70. IF: 5.395 (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071757/
  • Christofoletti M, Collings P, Tharrey M, Perchoux C, Malisoux L. Ten-Year Changes in the Physical Activity and Sedentary Behaviors of Adults: An Analysis of the 2 Cross-Sectional Observation of Cardiovascular Risk Factors in Luxembourg Studies. J Phys Act Health; 2023. 20(11):1043-1050.  https://pubmed.ncbi.nlm.nih.gov/37604484/
  • Collings PJ, Backes A, Malisoux L; ORISCAV-LUX study group. Arterial stiffness and the reallocation of time between device-measured 24-hour movement behaviours: A compositional data analysis. Atherosclerosis. 2023; 379:117185. https://pubmed.ncbi.nlm.nih.gov/37531669/
  • Collings, P. J., A. Backes, G. A. Aguayo, L. Malisoux, and Oriscav-Lux study group. Device-measured physical activity and sedentary time in a national sample of Luxembourg residents: the ORISCAV-LUX 2 study. Int J Behav Nutr Phys Act. 2022, 19:161. IF: 8.925 (2021). https://ijbnpa.biomedcentral.com/articles/10.1186/s12966-022-01380-3
  • Backes, A., G. A. Aguayo, P. J. Collings, D. El Fatouhi, G. Fagherazzi, L. Malisoux, and Oriscav-Lux Study Group. Associations Between Wearable-Specific Indicators of Physical Activity Behaviour and Insulin Sensitivity and Glycated Haemoglobin in the General Population: Results from the ORISCAV-LUX 2 Study. Sports Med Open. 2022; 8: 146. . IF; 6.31 (2021). https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-022-00541-9
  • Al Kudsee, K., F. Vahid, and T. Bohn. High adherence to the Mediterranean diet and Alternative Healthy Eating Index are associated with reduced odds of metabolic syndrome and its components in participants of the ORISCAV-LUX2 study, Front. Nutr. 2022; 9:1087985. IF; 6.008 (2021). https://www.frontiersin.org/articles/10.3389/fnut.2022.1087985/full
  • Zhou, Bin, Rodrigo M Carrillo-Larco, Goodarz Danaei, Leanne M Riley, Christopher J Paciorek, Gretchen A Stevens, Edward W Gregg, James E Bennett, Bethlehem Solomon, and Rosie K Singleton. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. The Lancet. 2021; 398: 957-80. IF 202.731 (2021). https://www.thelancet.com/article/S0140-6736(21)01330-1/fulltext
  • Vahid F, Brito A, Le Coroller G, Vaillant M, Samouda H, Bohn T, On Behalf Of Oriscav Working Group Dietary Intake of Adult Residents in Luxembourg Taking Part in Two Cross-Sectional Studies—ORISCAV-LUX (2007–2008) and ORISCAV-LUX 2 (2016–2017). Nutrients. 2021;13(12):4382. IF: 6.706 (2021). https://pubmed.ncbi.nlm.nih.gov/34959934/
  • Peng, F. J., C. Emond, E. M. Hardy, N. Sauvageot, A. Alkerwi, M. L. Lair, B. M. R. Appenzeller and the NESCAV  project group of the Grand Duchy of Luxembourg. Population-based biomonitoring of exposure to persistent and non-persistent organic pollutants in the Grand Duchy of Luxembourg: Results from hair analysis. Environ Int; 2021, 153: 106526. https://www-sciencedirect-com.proxy.bnl.lu/science/article/pii/S0160412021001513
  • Rollet M, Bohn T, Vahid F, On Behalf Of The Oriscav Working Group. Association between Dietary Factors and Constipation in Adults Living in Luxembourg and Taking Part in the ORISCAV-LUX 2 Survey. Nutrients. 2022;14(1):122. IF: 6.706 (2021) https://pubmed.ncbi.nlm.nih.gov/35010999/
  • NCD Risk Factor Collaboration (NCD-RisC) (Collaborators from LIH: Alkerwi A, Huiart L, Le Coroller G, Ruiz-Castell M). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. The Lancet. 2021 Sep 11;398(10304):957-980. IF 202.731 (2021) https://pubmed.ncbi.nlm.nih.gov/34450083/
  • Collaboration, NCD Risk Factor. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight. eLife, 2021(10)e60060. IF 8.713 (2021).  https://elifesciences.org/articles/60060
  • Aguayo G, Pastore J, Backes A, Stranges S, Witte DR, Diederich NJ, Alkerwi A, Huiart L, Ruiz-Castell M, Malisoux L, Fagherazzi G, Oriscav-Lux Study Group. Objective and subjective sleep measures are associated with HbA1c and insulin sensitivity in the general population: Findings from the ORISCAV-LUX-2 study. Diabetes Metab. 2021;48(1):101263. IF 8.254 (2021). https://pubmed.ncbi.nlm.nih.gov/34023494/
  • Fagherazzi G, Zhang L, Aguayo G, Pastore J, Goetzinger C, Fischer A, Malisoux L, Samouda H, Bohn T, Ruiz-Castell M, Huiart L. Towards precision cardiometabolic prevention: results from a machine learning, semi-supervised clustering approach in the nationwide population-based ORISCAV-LUX 2 study. Scientific reports. 2021; 11(1):16056. IF: 4.996 (2021). https://www.nature.com/articles/s41598-021-95487-5
  • Alkerwi A, Pastore J, Sauvageot N, Coroller GL, Bocquet V, d’Incau M, Aguayo G, Appenzeller B, Bejko D, Bohn T, Malisoux L, Couffignal S, Noppe S, Delagardelle C, Beissel J, Chioti A, Stranges S, Schmit JC. Challenges and benefits of integrating diverse sampling strategies in the observation of cardiovascular risk factors (ORISCAV-LUX 2) study. BMC Medical Research Methodology. 2019; 19(1): 27. IF: 3.031 (2019). https://www.ncbi.nlm.nih.gov/pubmed/30717671

Only ORISCAV 1

  • Alkerwi A, Baydarlioglu B, Sauvageot N, Stranges S, Lemmens P, Shivappa N, Hebert JR. Reply-Letter to the Editor – Smoking status is inversely associated with overall diet quality: Findings from the ORISCAV-LUX study. Clinical Nutrition. 2018; 37(2): 761-762. Epub 2018 Feb 15. IF: 6.402 (2018) – NA Reply. https://www.ncbi.nlm.nih.gov/pubmed/29439806
  • Alkerwi A. L’étude ORISCAV-LUX au service de la santé publique. Semper Luxembourg. 2018; (107): 24-26. IF: NA – National magazine. http://www.dsb.lu/archives/ipad/semper107.pdf
  • Alkerwi A, Sauvageot N, El Bahi I, Delagardelle C, Beissel J, Noppe S, Roderick PJ, Mindell JS, Stranges S. Prevalence and related risk factors of chronic kidney disease among adults in Luxembourg: evidence from the observation of cardiovascular risk factors (ORISCAV-LUX) study. BMC Nephrology. 2017; 18(1): 358. IF: 2.395 (2017). https://www.ncbi.nlm.nih.gov/pubmed/29221436
  • Alkerwi A, Baydarlioglu B, Sauvageot N, Stranges S, Lemmens P, Shivappa N, Hebert JR. Smoking status is inversely associated with overall diet quality: Findings from the ORISCAV-LUX study. Clinical Nutrition. 2017; 36(5): 1275-1282. Epub 2016 Aug 24. IF: 5.496 (2017). https://www.ncbi.nlm.nih.gov/pubmed/27595637
  • Columeau A, d’Incau M. Rôle de l’Infirmier de Recherche au Luxembourg Institute of Health: exemple dans le cadre de l’étude ORISCAV-LUX2. Semper Luxembourg. 2016; (85): 36-38. IF: NA – National magazine. http://www.dsb.lu/archives/ipad/semper85.pdf
  • Alkerwi A, Vernier C, Crichton GE, Sauvageot N, Shivappa N, Hebert JR. Cross-comparison of diet quality indices for predicting chronic disease risk: findings from the Observation of Cardiovascular Risk Factors in Luxembourg (ORISCAV-LUX) study. The British Journal of Nutrition. 2015; 113(2): 259-69. Epub 2014 Dec 5. IF: 3.311 (2015). https://www.ncbi.nlm.nih.gov/pubmed/25475010
  • Alkerwi A, Sauvageot N, Malan L, Shivappa N, Hebert JR. Association between nutritional awareness and diet quality: evidence from the observation of cardiovascular risk factors in Luxembourg (ORISCAV-LUX) study. Nutrients. 2015; 7(4): 2823-38. IF: 3.759 (2015). https://www.ncbi.nlm.nih.gov/pubmed/25875122
  • Alkerwi A, Sauvageot N, Gilson G, Stranges S. Prevalence and correlates of vitamin D deficiency and insufficiency in Luxembourg adults: evidence from the observation of cardiovascular risk factors (ORISCAV-LUX) study. Nutrients. 2015; 7(8): 6780-96. IF: 3.759 (2015). https://www.ncbi.nlm.nih.gov/pubmed/26287235
  • Alkerwi A, Sauvageot N, Buckley JD, Donneau AF, Albert A, Guillaume M, Crichton GE. The potential impact of animal protein intake on global and central obesity: evidence from the ORISCAV-LUX study. Public Health Nutrition. 2015; 18(10): 1831-8. Epub 2015 Jan 22. IF: 2.433 (2015). https://www.ncbi.nlm.nih.gov/pubmed/25611401
  • Alkerwi A, Crichton GE, Hebert JR. Consumption of ready-made meals and increased risk of obesity: findings from the Observation of Cardiovascular Risk Factors in Luxembourg (ORISCAV-LUX) study. The British journal of Nutrition. 2015; 113(2): 270-7. Epub 2014 Dec 9. IF: 3.311 (2015). https://www.ncbi.nlm.nih.gov/pubmed/25488071
  • Crichton GE, Elias MF, Davey A, Sauvageot N, Delagardelle C, Beissel J, Alkerwi A. Cardiovascular health: a cross-national comparison between the Maine Syracuse Study (Central New York, USA) and ORISCAV-LUX (Luxembourg). BMC Public Health. 2014; 14(1): 253. IF: 2.264 (2014). https://www.ncbi.nlm.nih.gov/pubmed/24628938
  • Crichton GE, Alkerwi A. Association of sedentary behavior time with ideal cardiovascular health: the ORISCAV-LUX study. PLoS One. 2014; 9(6): e99829. IF: 3.234 (2014). https://www.ncbi.nlm.nih.gov/pubmed/24925084
  • Alkerwi A, Sauvageot N, Nau A, Couffignal S, Lair ML. L’adhésion aux recommandations nationales nutritionnelles chez les adultes résidant au Luxembourg, en 2007-2008: Résultats de l’étude ORISCAV-LUX « Observation des Risques et de la Santé Cardiovasculaire au Luxembourg ». Enjeux Santé – Bulletin luxembourgeois de la recherche et des études en santé publique. 2013; (5): 1-24. IF: NA (2013). http://www.sante.public.lu/fr/publications/e/enjeux-sante-recommandations-nutritionnelles/index.html
  • Alkerwi A, Pagny S, Lair ML, Delagardelle C, Beissel J. Level of unawareness and management of diabetes, hypertension, and dyslipidemia among adults in Luxembourg: findings from ORISCAV-LUX study. PLoS One. 2013; 8(3): e57920. Epub 2013 Mar 4. IF: 3.534 (2013). https://www.ncbi.nlm.nih.gov/pubmed/23483942
  • Alkerwi A, Sauvageot N, Pagny S, Beissel J, Delagardelle C, Lair ML. Acculturation, immigration status and cardiovascular risk factors among Portuguese immigrants to Luxembourg: findings from ORISCAV-LUX study. BMC Public Health. 2012; 12(1): 864. IF: 2.076 (2012). https://www.ncbi.nlm.nih.gov/pubmed/23057477
  • Alkerwi A, Sauvageot N, Nau A, Lair ML, Donneau AF, Albert A, Guillaume M. Population compliance with national dietary recommendations and its determinants: findings from the ORISCAV-LUX study. The British Journal of Nutrition. 2012; 108(11): 2083-92. Epub 2012 Feb 7. IF: 3.302 (2012). https://www.ncbi.nlm.nih.gov/pubmed/22313864
  • Alkerwi A, Donneau AF, Sauvageot N, Lair ML, Albert A, Guillaume M. Dietary, behavioural and socio-economic determinants of the metabolic syndrome among adults in Luxembourg: findings from the ORISCAV-LUX study. Public Health Nutrition. 2012; 15(5): 849-59. Epub 2011 Sep 14. IF: 2.250 (2012). https://www.ncbi.nlm.nih.gov/pubmed/21914256
  • Alkerwi A, Donneau AF, Sauvageot N, Lair ML, Scheen A, Albert A, Guillaume M. Prevalence of the metabolic syndrome in Luxembourg according to the Joint Interim Statement definition estimated from the ORISCAV-LUX study. BMC Public Health. 2011; 11(1): 4. IF: 1.997 (2011) https://www.ncbi.nlm.nih.gov/pubmed/21205296
  • Alkerwi A, Sauvageot N, Donneau AF, Lair ML, Couffignal S, Beissel J, Delagardelle C, Wagener Y, Albert A, Guillaume M. First nationwide survey on cardiovascular risk factors in Grand-Duchy of Luxembourg (ORISCAV-LUX). BMC Public Health. 2010; 10: 468. IF: 2.364 (2010). https://www.ncbi.nlm.nih.gov/pubmed/20698957
  • Alkerwi A, Sauvageot N, Couffignal S, Albert A, Lair ML, Guillaume M. Comparison of participants and non-participants to the ORISCAV-LUX population-based study on cardiovascular risk factors in Luxembourg. BMC Medical Research Methodology. 2010; 10(1): 80. IF: 2.153 (2010). https://www.ncbi.nlm.nih.gov/pubmed/20819238