🇬🇧 Computational metagenomics to mine the hidden diversity of the human microbiome » Luxembourg Institute of Health
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🇬🇧 Computational metagenomics to mine the hidden diversity of the human microbiome

18/12/2023 11:00 an 14:00
  • Lecture Series Infection & Immunity

Speakers

Prof. Nicola
Segata

Full Professor and Principal Investigator
Department CIBIO, University of Trento, Italy

Abstract

Shotgun metagenomics has uncovered a substantial amount of diversity in the human microbiome, but a large fraction of the sequences in a metagenome remains uncharacterized. In my talk I will show how the combination of multiple reference-based and assembly-based computational approaches applied on several thousand of diverse human metagenomes can lead to the discovery of hundreds of previously unknown species and strain-level variants of known species. Cataloging this diversity and exploiting it for large-scale study and be􀆩er characterization of metagenomes is now possible and enables linking previously uncharacterized taxa with host conditions and studying the evolutionary trajectories and person-to-person transmission
of commensal microbes. Mining such hidden human microbiome diversity has also a number of biomedical applications and I will conclude my talk discussing translational initiatives ranging from screening tools for
cancer and other disease, to model and support fecal microbiota transplantation interventions, to novel personalized nutrition approaches.


Responsible Scientist
Mahesh
Desai

LOCATION

House of BioHealth
Conference Room (ground floor 0)

29, rue Henri Koch, L-4354 Esch-sur-Alzette

LECTURE: 11:00am – 12:00pm

Please note that registration is mandatory by sending an email to carole.weis@lih.lu or michelle.roderes@lih.lu

MEET & EAT

12:30pm – 14:00pm

House of BioHealth
Salle Françoise Barré Sinoussi

29, rue Henri Koch, L-4354 Esch-sur-Alzette

Registration mandatory

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