Home » Events » Lecture Series Cancer Research – “Identiﬁcation and characterization of cell-of-origin DNA methylation signatures in human cancers” – Prof Frank Lyko
Tumors are currently deﬁned at the organ level and then further classiﬁed by pathological assessment and molecular analysis. However, these classiﬁcation schemes do not necessarily reﬂect the biological makeup of tumors, which originate from a deﬁned pool of cells-of-origin. The human body contains more than 100 cell types which are epigenetically programmed by DNA methylation. Of note, we and others have used genome-wide methylation proﬁling to show that cell type-speciﬁc DNA methylation patterns are maintained from the cancer cell-of-origin to the fully developed tumor and I will illustrate this approach using colorectal cancer and non-melanoma skin cancer as examples. Our ﬁndings provide an opportunity for the establishment of a biologically deﬁned diagnostics scheme that classiﬁes tumors according to their cell-of-origin.
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