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Glioma cellular heterogeneity in space and time

13/10/2025 11:00 to 13:00
  • Lecture Series Cancer Research

Speakers

Prof Itay
Tiroh

Principal Investigator, Dept. Of Molecular Cell Biology,
Weizmann Institute of Science

Abstract

One of the main barriers for successful treatments of glioma is the diversity of cells within each tumor. We have previously defined the patterns of cellular diversity in several types of glioma, including glioblastoma and
IDH-mutant glioma, highlighting few recurring cellular states in each glioma type.

I will describe recent studies in which
we examine how these states are spatially organized and how they change following treatments and recurrence. Spatially, we find that some tumor samples are disorganized while others have a stereotypical organization composed of five layers. These layers highlight the role of hypoxia as a tissue organizer. We also explore the states of cells outside of the tumor – those that invade the brain parenchyma and
that cause gliomas to recur. Following treatments, we find that cells in most gliomas maintain largely the same states that are observed in the primary tumors.

However, tumors with evidence of treatment response show specific signatures of those responses. In particular, in IDH-mutant glioma we find that new treatments induce cellular differentiation, highlighting the potential of differentiation therapies in the context of glioma.


Host
Luxembourg Institute of Health
Responsible Scientist
Alessandro
Michelucci

LOCATION

Lecture:
CHL – Centre
Room: Amphitheatre
4, rue Ernest Barblé
L-1210 Luxembourg

LECTURE: 11:00am – 12:00pm

Webinar via Webex:
Event number: 2790 737 8560
Event password: krV4pwb5ZZ9

MEET & EAT

12:00pm – 13:00pm
Room Barbara Mc Clintock

Light lunch provided *Please note that registration for Meet and Eat is mandatory via the following link:

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