🇬🇧 Harnessing tumor metabolism to overcome immunosuppression » Luxembourg Institute of Health
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🇬🇧 Harnessing tumor metabolism to overcome immunosuppression

25/09/2025 11:00 to 13:00
  • Lecture Series Cancer Research

Speakers

Prof Massimiliano
Mazzone

Professor; Head of the Lab of Tumor Inflammation and Angiogenesis
VIB – KU Leuven Center for Cancer Biology

Abstract

Anti-cancer immunotherapy has provided patients with a promising treatment. Yet, it has also unveiled that the
immunosuppressive tumor microenvironment (TME)
hampers the efficiency of this therapeutic option and limits its success. The concept that metabolism is able to shape the immune response has gained general acceptance. Nonetheless, little is known on how the metabolic crosstalk between different tumor compartments contributes to the harsh TME and ultimately impairs T cell fitness within the tumor.

This lecture will decipher some of the metabolic
changes in the TME impeding proper anti-tumor immunity. Starting from the meta-analysis of public human datasets, corroborated by metabolomics and transcriptomics data from several mouse tumors, we ranked clinically relevant and altered metabolic pathways that correlate with resistance to immunotherapy. Using a CRISPR/Cas9 platform
for their functional in vivo selection, we have identified
cancer cell intrinsic metabolic mediators and, indirectly,
distinguished those belonging specifically to the stroma.

By means of genetic tools and small molecules, we have
targeted promising metabolic pathways in cancer cells and stromal cells (particularly in tumor-associated macrophages) to harness tumor immunosuppression. Finally, we went back to patient samples to assess the relevance of these metabolic networks in humans. By analyzing the metabolic crosstalk within the TME, this lecture would like to shed some light on how metabolism contributes to the immunosuppressive TME and T cell maladaptation.


Host
Luxembourg Institute of Health
Responsible Scientist
Johannes
Meiser
Elisabeth
Letellier

LOCATION

Lecture:
CHL – Centre
Room: Amphitheatre
4, rue Ernest Barblé
L-1210 Luxembourg

LECTURE: 11:00am – 12:00pm

Webinar via Webex:
Event number: 2780 195 4400
Event password: 3ARrHTtCW53

MEET & EAT

12:00pm – 13:00pm
Room Barbara Mc Clintock

Light lunch provided *Please note that registration for Meet and Eat is mandatory via the following link:

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