🇬🇧 Metabolically co-opting tissue resident macrophages in cancer » Luxembourg Institute of Health
Accueil » Événements » 🇬🇧 Metabolically co-opting tissue resident macrophages in cancer

🇬🇧 Metabolically co-opting tissue resident macrophages in cancer

15/02/2024 11:00 Ă  14:00
  • Lecture Series Infection & Immunity


Prof. Dr Susan

NOMIS Center for Immunobiology and Microbial Pathogenesis


Cancer, fundamentally a disease of deregulated tissue homeostasis, substantially alters the composition of the surrounding tumor microenvironment (TME). Resident immune cells are uniquely situated within the TME to respond to the shifting environment in a way that optimally supports client malignant epithelium. This talk will discuss the ways in which homeostatic metabolic macrophage programs can be co-opted during tumorigenesis to create an immunologically permissive and metabolically supportive TME. In a mouse model of lung adenocarcinoma we identified an accumulation of resident alveolar macrophages during tumorigenesis which was necessary for optimal tumor growth. These cells became increasingly tolerogenic, while also dramatically increasing their lipid metabolism. We found that, by engaging the pathways generally expressed in AMs for surfactant catabolism, tumors were able to re-wire macrophage metabolism, resulting in more suppressive cells, and creating a nutritionally supportive environment. This talk will discuss the pathways involved by which macrophage and epithelial cell cross talk in cancer mediates the immunological and metabolic tumor landscape.

Responsible Scientist


House of BioHealth
Conference Room (ground floor 0)

29, rue Henri Koch, L-4354 Esch-sur-Alzette

LECTURE: 11:00am – 12:00pm

Please note that registration is mandatory by sending an email to carole.weis@lih.lu or michelle.roderes@lih.lu


12:30pm – 14:00pm

House of BioHealth
Salle Françoise Barré Sinoussi

29, rue Henri Koch, L-4354 Esch-sur-Alzette

Light lunch provided – Registration mandatory

Supported by:

Partagez sur

Protection des données

En savoir plus sur la « Notice sur la protection des données : traitement des données personnelles dans le cadre de la gestion des événements  ».

Événements à venir