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🇬🇧 Proteomics and functional investigation of Small Ubiquitin-like Modifier signaling networks

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21/02/2024 11:00 Ă  13:45
  • Lecture Series Infection & Immunity – Next-generation of multi-omics research:going to the single cell


Prof Dr Afredus

Leiden University Medical Center, department of Cell & Chemical Biology, NL

SUMOylation is an essential post-translational modification that is catalysed by a small number of modifying enzymes but regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins as one or more monomers or in the form of polymers of different types. Non-covalent readers recognize SUMO-modified
proteins via SUMO interaction motifs. Recent progress has increased our understanding of the cellular and pathophysiological roles of SUMO modifications, extending their functions to the regulation of immunity, pluripotency and nuclear body assembly in response to oxidative stress, which partly occurs through the recently characterized mechanism of liquid-liquid phase separation. Such progress in understanding the roles and regulation of sumoylation opens new avenues for the targeting of SUMO to treat disease, and indeed the first drug blocking sumoylation is currently under investigation in clinical trials as a possible anticancer agent.

We have uncovered dynamic SUMO signaling networks in a cell-wide manner using proteomics technology. Denaturing buffer conditions are critical to inactivate SUMO proteases. We have developed site-specific methodology to identify SUMO acceptor lysines and found that SUMO targets over 40,000 lysines in nearly 7,000 target proteins, highlighting the broad impact of this
post-translational modifier. SUMOylation plays dynamic roles during cell cycle progression, the DNA damage response and upon proteotoxic stress and proteomic approaches enable uncovering SUMOylation dynamics during these processes. SUMO simultaneously modifies groups of functionally related proteins to regulate these processes. I will highlight our contributions to
uncovering these dynamic SUMOylation networks.

Responsible Scientist


11:00am – 12:00pm
Maison du Savoir, Uni LU (Room: MSA 3.100)

2, Av. de l’UniversitĂ©, Belval Esch-sur-Alzette

12:00pm – 1:45pm
Light lunch provided
KKT (BT2, 1st floor)

Event number: 2783 570 5067
Event password: 7rA9tN3AB5W


For any questions regarding the Lecture Series please email: omics-lecture@lih.lu.

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