Post-Doctoral Fellow in Immuno-Oncology

The Translational Cancer Immunogenomics (TCI) Research Group, led by Dr. Ángel Álvarez-Prado at the Department of Cancer Research of LIH, is currently offering a postdoctoral researcher position. Established in 2025, the group focuses on understanding how genetic alterations in cancer cells shape the immune microenvironment of brain metastatic tumors, with the long-term goal of developing novel personalized immunotherapies for cancer patients with brain metastasis.

Our group works at the interface between immunology and cancer biology combining the use of preclinical models of cancer and human samples with state-of-the-art technologies to profile the immune microenvironment of brain metastatic tumors upon different therapeutic interventions. We are looking for a highly motivated postdoctoral researcher to join our lab and work on the recently funded ERC project “IMMUNAGENOMICS: Immunogenomic and ageing determinants of therapy response in brain metastasis”. The candidate will join a young, creative and stimulating environment, with mentoring by the Principal Investigator and opportunities for professional growth and direct involvement in research projects including national and international collaboration partners.

Key Skills, Experience and Qualifications

• Ph.D. in immuno-oncology, immunology or oncology.
• Hands-on experience in biochemistry, molecular biology, cell culture, flow cytometry and immunofluorescence techniques.
• Experience handling preclinical mouse models of cancer and certified training on animal experimentation and welfare corresponding to the requirements defined by the EU Directive 2010/63/EU and the Réglement Grand-Ducal of the 11th January 2013 (FELASA or equivalent) is a must.
• Experience with preclinical mouse models of brain cancer will be a plus.
• Experience operating magnetic resonance imaging (MRI) or focalized X-ray irradiator devices will be a plus.
• Experience on bioinformatic analyses (WES/WGS, (sc)RNA-Seq, ChIP-Seq, ATAC-Seq, Proteomics, Spatial Transcriptomics) and/or R programming skills will be a plus.
• Experience supervising students will be a plus.
• Skills: Curiosity, rigor, perseverance, creativity, excellent time management and sense of priority, independence, ability to effectively communicate scientific results (oral and written), team player.
• Fluent command of English (written and spoken) is a must.

The starting date can be negotiated but the 1st September 2026 would be preferred.
The contract is renewable for up to 5 years.

For any further information, please contact Dr. Ángel Álvarez-Prado at angel.alvarez@lih.lu.