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Wichtige aktuelle Veröffentlichungen, die aus der PRECISION-PDX-Sammlung hervorgegangen sind:
Rezaeipour, M., de Lucas Sanz, M., Allahverdi, H., Triballier, G., Klein, E., Salvato, I., Moreno-Sanchez, P. M., Nosirov, B., Nazarov, P. V., Kisakol, B., Dussmann, H., Connolly, C., Byrne, A. T., Prehn, J. H. M., Brenner, D., Janji, B., Niclou, S. P. & Golebiewska, A. Advanced 3D patient-derived glioblastoma organoid-immune cell co-cultures reveal preserved MHC-I tumor cell surface expression and tumor cell-driven T-cell dysfunction. Journal of Neuroinflammation (2026). | Link
Scafidi, A., Kaoma T. Cerella C., Campus E., Grzyb K., Nosirov B., Lind-Holm Mogensen F., Klein E., Da Costa R., Skupin A. , Hertel F., Berchem G., Mittelbronn M., Cosma A., Melin B., Niclou S.P., Nazarov P. V., Golebiewska, A., Poli A. and Michelucci A. (2026). Circulating immune profiling reveals impaired monocyte states and trajectories driving immunosuppression in glioblastoma. J Neuroinflammation (2026). | Link
Johnson KC, Spitzer A, Varn FS, Nomura M, Garofano L, Chowdhury T, Lipsa A, Zhang L, Fernández EC, Barak T, Gulhan Ercan-Sencicek A, Peksen AB, Anderson KJ, Tesileanu CMS, Amin SB, Kocakavuk E, Zhao D, D’Angelo F, Migliozzi S, Bussema L, Gritsch S, Moon HE, Paek SH, Bielle F, Laurenge A, Di Stefano AL, Mathon B, Picca A, Sanson M, Hau AC, Hertel F, Grzyb K, Zhao Z, Wang Q, Jiang T, Miller JJ, Wakimoto H, Cahill DP, Moliterno J, Günel M, Hermes B, Sanai N, Golebiewska A, Niclou SP, Huse J, Alfred Yung WK, Lasorella A, Suvà ML, Iavarone A, Tirosh I, Verhaak RGW. Acquired genetic and cell state changes underlie IDH-mutant glioma progression. Nature. 2026 Jun 3. | Link.
Spitzer A, Johnson KC, Nomura M, Garofano L, Nehar-belaid D, Darnell NG, Greenwald AC, Bussema L, Oh YT, Varn FS, D’Angelo F, Gritsch S, Anderson KJ, Migliozzi S, Gonzalez Castro LN, Chowdhury T, Robine N, Reeves C, Park JB, Lipsa A, Hertel F, Golebiewska A, Niclou SP, Nusrat L, Kellet S, Das S, Moon HE, Paek SH, Bielle F, Laurenge A, Di Stefano AL, Mathon B, Picca A, Sanson M, Tanaka S, Saito N, Ashley DM, Keir ST, Huse JT, Yung WKA, Lasorella A, Iavarone A, Verhaak RGW, Tirosh I, Suvà ML, Deciphering the Longitudinal Trajectories of Glioblastoma Ecosystems by Integrative Single-Cell Genomics, Nature Genetics, (2025). | Link
Nomura M, Spitzer A, Johnson KC, Nehar-belaid D, Darnell NG, Greenwald AC, Bussema L, Oh YT, Varn FS, D’Angelo F, Gritsch S, Anderson KJ, Migliozzi S, Gonzalez Castro LN, Chowdhury T, Robine N, Reeves C, Park JB, Lipsa A, Hertel F, Golebiewska A, Niclou SP, Nusrat L, Kellet S, Das S, Moon HE, Paek SH, Bielle F, Laurenge A, Di Stefano AL, Mathon B, Picca A, Sanson M, Tanaka S, Saito N, Ashley DM, Keir ST, Huse JT, Yung WKA, Lasorella A, Verhaak RGW, Iavarone A, Suvà ML, Tirosh I The Multi-Layered Transcriptional Architecture of Glioblastoma Ecosystems, Nature Genetics, (2025). | Link
Yabo YA, Moreno-Sanchez PM, Pires-Afonso Y, Kaoma T, Nosirov B, Scafidi A, Ermini L, Lipsa A, Kyriakis D, Grzyb K, Poovathingal SK, Poli A, Muller A, Toth R, Oudin A, Klink B, Berchem G, Berthold C, Hertel F, Mittelbronn M, Heiland DH, Skupin A, Nazarov PV, Niclou SP, Michelucci A, Golebiewska A; Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts; Genome Medicine 2024. | Link
Oudin A, Baus V, Barthelemy V, Fabian C, Klein E, Dieterle M, Wantz M, Hau AC, Dording C, Bernard A, Michelucci A, Yabo YA, Kanli G, Keunen O, Bjerkvig R, Niclou SP, Golebiewska A. Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors. STAR Protoc. 2021 May 12;2(2):100534. doi: 10.1016/j.xpro.2021.100534 | Link
Golebiewska A*, Hau A-C*, Oudin A*, Stieber D, Yabo Y A, Baus V, Barthelemy V, Klein E, Bougnaud S, Keunen O, Wantz M, Michelucci A, Neirinckx V, Muller A, Kaoma T, Nazarov P V, Azuaje F, de Falco A, Flies B, Poovathingal S, Arns T, Grzyb K, Mock A, Herold-Mende C, Steino A, Brown D, May P, Miletic H, Noushmehr H, Kwon Y-J, Jahn W, Klink B, Tanner G, Stead LF, Mittelbronn M, Skupin A, Hertel F, Bjerkvig R and Niclou SP; Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology. Acta Neuropathologica, Oct 2020. | Link
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