Immunological disorders

LIH builds on ongoing work in allergy research to study and understand the early onset, impact of environmental factors and predisposition to diseases with a strong immunological component.

Since allergic diseases often manifest themselves very early in life, this indicates that the developing immune system is particularly vulnerable to environmental influences. Together with defective skin and intestinal barriers in children, these early-life events, environmental and lifestyle factors therefore play a crucial role in the onset and progression of allergic diseases. Understanding how these factors interact is vital for the foundation of future strategies of allergy prevention.

LIH research therefore concentrates on translational activities, with a particular focus on elucidating predisposition and development of allergic diseases in children. To this end, a close collaboration with the National Service of Allergy and Clinical Immunology at the Centre Hospitalier de Luxembourg (CHL) has already been established.

Additional chronic immunological disease programmes that build on these findings are being set up, including Multiple Sclerosis (MS), Rheumatoid Arthritis (RA) and Inflammatory Bowel Disease (IBD).

LIH research groups

Several LIH research groups are currently working on this highly transversal priority area, integrating a broad set of in-house methodologies and capacities — ranging from ‘-omic’ approaches to epidemiology, exposure measurement and digital health expertise — thus studying these diseases from different angles in a truly holistic way.

Discover the different research groups below.