In a new study led by the Immune Systems Biology research group of the LIH Department of Infection and Immunity, researchers adopted a holistic machine-learning approach to elucidate how the interactions between neuronal mitochondria can serve as a powerful tool to distinguish nerve cells from Parkinson’s patients from those belonging to healthy subjects, thereby providing new insights in the pathogenesis, diagnosis and treatment of this neurodegenerative disorder. The results were published today in the renowned journal ‘Nature Partner Journals Systems Biology and Application’.

WEBINAR: Lecture series Cancer Research: "Mechanisms driving cell plasticity in the colorectal tumor microenvironment"- Prof Florian Greten

The NORLUX Neuro-Oncology Laboratory at the LIH Department of Oncology (DONC), in collaboration with the Centre Hospitalier de Luxembourg (CHL), the Laboratoire National de Santé (LNS), the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and other international partners, established a large collection of patient-derived glioma organoids and xenograft models that mimic the specific features of patient brain tumours. These tools will allow the establishment of personalised drug efficacy studies, thus increasing the chances of success of clinical trials and improving clinical outcomes for patients. The findings were presented in a recent publication in the international peer-reviewed journal Acta Neuropathologica.

WEBINAR: Lecture series Infection & Immunity: "Transcriptional and metabolic regulation of long-term T cell responses in chronic infection"- Prof Axel Kallies

Running is good for your health. Medical experts and the general public agree on this.

The LIH is not only a privileged research partner in Luxembourg, but also worldwide as a lead institution in large-scale collaborative initiatives.

WEBINAR: Lecture series Cancer Research: "Challenges in brain tumor immunotherapy"- Prof Michael Platten

Hypoxia, a decrease in the oxygen pressure, is a major factor developed in the microenvironment of all solid tumors. Tumor cells are able to adapt to hypoxic stress by activating multiple resistance mechanisms, which collectively contribute to the failure of conventional cancer treatments, such as chemo and radiation therapy. However, data underlining the tangible impact of hypoxia on the efficacy of immunotherapy are still missing.

Lecture series Infection & Immunity: "Spontaneous protein crystallization as a treatable trait in asthma"- Prof Bart Lambrecht