Activities

Beyond their role in preventing genetic instability and tumorigenesis, DNA repair and epigenetic mechanisms also contribute to the resistance of cancer cells to chemotherapeutic genotoxics. These mechanisms are responsible in great part for the failure of current anti-glioma therapies. Our research group is developing several approaches (including differential shRNA screens, multiplexed gene expression analyses and studies in xenograft animal models) to better understand the DNA repair and epigenetic factors that operate in glioblastoma and identify critical therapeutic targets to prevent chemoresistance.

A second line of investigation explores fundamental aspects of the mechanisms underlying centromere dynamics as well as heterochromatin expression in mammalian cells.

Close collaborators include Drs R. Golbrunner and M. Timmer (Uniklinik Köln), Drs F. Sholtes and D. Martin (CHU Liège) and Dr Y.G. Yang (Beijing Institute of Genomics).

Research projects

  • Identification of novel molecular targets for temozolomide-based therapies against glioblastoma: a comprehensive shRNA-based screen of DNA damage response factors.
  • Impact of DNA repair genes and associated miRNAs in GBM biology and resistance to temozolomide: study of TMZ-positive and TMZ-negative GBM cohorts.
  • Epigenetic factors mediating heat-shock-induced expression of heterochromatin in human cells.

Featured Publications

Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the glioma longitudinal AnalySiS Consortium.

  • NORLUX-Glioma Biology
February 08, 2018
2018 Feb. Neuro Oncol. [Epub ahead of print].
By:
  • Aldape K
  • Amin SB
  • Ashley DM
  • Barnholtz-Sloan JS
  • Bates AJ
  • Beroukhim R
  • Bock C
  • Brat DJ
  • Claus EB
  • Costello JF
  • de Groot JF
  • Finocchiaro G
  • French PJ
  • Gan HK
  • Griffith B
  • Herold-Mende CC
  • Horbinski C
  • Iavarone A
  • Kalkanis SN
  • Karabatsou K
  • Kim H
  • Kouwenhoven MCM
  • McDonald KL
  • Miletic H
  • Nam DH
  • Ng HK
  • Niclou SP
  • Noushmehr H
  • Ormond R
  • Poisson LM
  • Reifenberger G
  • Roncaroli F
  • Sa JK
  • Sillevis Smitt PAE
  • Smits M
  • Souza CF
  • Tabatabai G
  • Van Meir EG
  • Verhaak RGW
  • Watts C
  • Wesseling P
  • Woehrer A
  • Yung WKA
  • Jungk C
  • Hau AC
  • van Dyck E
  • Westerman BA
  • Yin J
  • Abiola O
  • Zeps N
  • Grimmond S
  • Buckland M
  • Khasraw M
  • Sulman EP
  • Muscat AM
  • Stead L
  • Glass Consortium.

DNA repair mechanisms and their clinical impact in glioblastoma.

  • NORLUX-DNA repair and chemoresistance
  • NORLUX-Glioma Biology
June 21, 2016
2016 Jun. Mutat Res Rev Mutat Res.769:19-35. Epub 2016 Jun 21.
By:
  • Erasimus H
  • Gobin M
  • Niclou S
  • Van Dyck E.
See all publications

Contact

Eric Van Dyck

Ph.D.

84, rue Val Fleuri
L-1526 Luxembourg
Luxembourg
Tel. : +352 26970-239