Activities

Beyond their role in preventing genetic instability and tumorigenesis, DNA repair and epigenetic mechanisms also contribute to the resistance of cancer cells to chemotherapeutic genotoxics. These mechanisms are responsible in great part for the failure of current anti-glioma therapies. Our research group is developing several approaches (including differential shRNA screens, multiplexed gene expression analyses and studies in xenograft animal models) to better understand the DNA repair and epigenetic factors that operate in glioblastoma and identify critical therapeutic targets to prevent chemoresistance.

A second line of investigation explores fundamental aspects of the mechanisms underlying centromere dynamics as well as heterochromatin expression in mammalian cells.

Close collaborators include Drs R. Golbrunner and M. Timmer (Uniklinik Köln), Drs F. Sholtes and D. Martin (CHU Liège) and Dr Y.G. Yang (Beijing Institute of Genomics).

Research projects

  • Identification of novel molecular targets for temozolomide-based therapies against glioblastoma: a comprehensive shRNA-based screen of DNA damage response factors.
  • Impact of DNA repair genes and associated miRNAs in GBM biology and resistance to temozolomide: study of TMZ-positive and TMZ-negative GBM cohorts.
  • Epigenetic factors mediating heat-shock-induced expression of heterochromatin in human cells.

Featured Publications

DNA repair mechanisms and their clinical impact in glioblastoma.

  • NORLUX-DNA repair and chemoresistance
  • NORLUX-Glioma Biology
June 21, 2016
2016 Jun. Mutat Res Rev Mutat Res.769:19-35. Epub 2016 Jun 21.
By:
  • Erasimus H
  • Gobin M
  • Niclou S
  • Van Dyck E.

Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-Cell chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • National Cytometry Platform
  • NORLUX-Glioma Biology
August 01, 2014
2014 Aug. Leukemia.28(8):1636-46. Epub 2014 Jan 14.
By:
  • El-Khoury V
  • Pierson S
  • Szwarcbart E
  • Brons NH
  • Roland O
  • Cherrier-De Wilde S
  • Plawny L
  • Van Dyck E
  • Berchem G.
See all publications

Contact

Eric Van Dyck

Ph.D.

84, rue Val Fleuri
L-1526 Luxembourg
Luxembourg
Tel. : +352 26970-239