Our research is focused on malignant brain tumours and aims to improve therapeutic options for these uncurable cancers. Patient tumors and patient derived xenograft models (PDX), which enable to translate novel treatment approaches into personalised medicine, are central to our work.

Our specific expertise and interests lie in tumour angiogenesis and invasion, tumour metabolism, and tumour cell heterogeneity and adaptability. Our research group is closely linked to the K.G. Jebsen Brain Tumour Research Center (University of Bergen, Norway), with joint research projects on glioma angiogenesis, metabolism and in vivo imaging, and has an extensive network of national and international collaborators.

Research projects

  • ADAPT: Adaptive capacities of glioblastoma: is there a role for cancer stem cells?
  • METABO: Aberrant tumour metabolism in gliomas.
  • INVGBM: Targeting glioma cell invasion.
  • CREG: Chemoresistance related RNAs in glioblastoma.
  • ANIMIX: Establishment of a national in vivo imaging platform.

Featured Publications

Increased formate overflow is a hallmark of oxidative cancer.

  • NORLUX-Glioma Biology
April 10, 2018
2018 Apr. Nat Commun.9(1):1368.
  • Meiser J
  • Schuster A
  • Pietzke M
  • Vande Voorde J
  • Athineos D
  • Oizel K
  • Burgos-Barragan G
  • Wit N
  • Dhayade S
  • Morton JP
  • Dornier E
  • Sumpton D
  • Mackay GM
  • Blyth K
  • Patel KJ
  • Niclou SP
  • Vazquez A.

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.

  • Tumor Stroma Interactions
  • National Cytometry Platform
  • Tumor Microenvironment
  • NORLUX-Glioma Biology
  • Allergy and Clinical Immunology
April 05, 2018
2018 Apr. Blood.131(14):1617-1621. Epub 2018 Feb 13.
  • Wierz M
  • Pierson S
  • Guyonnet L
  • Viry E
  • Lequeux A
  • Oudin A
  • Niclou SP
  • Ollert M
  • Berchem G
  • Janji B
  • Guerin C
  • Paggetti J
  • Moussay E.
See all publications


Simone Niclou


84, rue Val Fleuri
L-1526 Luxembourg
Tel. : +352 26970-273