Activities

Our research is focused on malignant brain tumours and aims to improve therapeutic options for these uncurable cancers. Patient tumors and patient derived xenograft models (PDX), which enable to translate novel treatment approaches into personalised medicine, are central to our work.

Our specific expertise and interests lie in tumour angiogenesis and invasion, tumour metabolism, and tumour cell heterogeneity and adaptability. Our research group is closely linked to the K.G. Jebsen Brain Tumour Research Center (University of Bergen, Norway), with joint research projects on glioma angiogenesis, metabolism and in vivo imaging, and has an extensive network of national and international collaborators.

Research projects

  • ADAPT: Adaptive capacities of glioblastoma: is there a role for cancer stem cells?
  • METABO: Aberrant tumour metabolism in gliomas.
  • INVGBM: Targeting glioma cell invasion.
  • CREG: Chemoresistance related RNAs in glioblastoma.
  • ANIMIX: Establishment of a national in vivo imaging platform.

Featured Publications

EGFL7 enhances surface expression of integrin alpha5beta1 to promote angiogenesis in malignant brain tumors.

  • NORLUX-Glioma Biology
  • In vivo imaging facility
  • Luxembourg Center of Neuropathology
July 31, 2018
2018 Jul. EMBO Mol Med. [Epub ahead of print].
By:
  • Dudvarski Stankovic N
  • Bicker F
  • Keller S
  • Jones DT
  • Harter PN
  • Kienzle A
  • Gillmann C
  • Arnold P
  • Golebiewska A
  • Keunen O
  • Giese A
  • von Deimling A
  • Bauerle T
  • Niclou SP
  • Mittelbronn M
  • Ye W
  • Pfister SM
  • Schmidt MH.

Glioma through the looking GLASS: Molecular evolution of diffuse gliomas and the Glioma Longitudinal AnalySiS Consortium.

  • NORLUX-Glioma Biology
June 18, 2018
2018 Jun. Neuro Oncol.20(7):873-884.
By:
  • Aldape K
  • Amin SB
  • Ashley DM
  • Barnholtz-Sloan JS
  • Bates AJ
  • Beroukhim R
  • Bock C
  • Brat DJ
  • Claus EB
  • Costello JF
  • de Groot JF
  • Finocchiaro G
  • French PJ
  • Gan HK
  • Griffith B
  • Herold-Mende CC
  • Horbinski C
  • Iavarone A
  • Kalkanis SN
  • Karabatsou K
  • Kim H
  • Kouwenhoven MCM
  • McDonald KL
  • Miletic H
  • Nam DH
  • Ng HK
  • Niclou SP
  • Noushmehr H
  • Ormond R
  • Poisson LM
  • Reifenberger G
  • Roncaroli F
  • Sa JK
  • Sillevis Smitt PAE
  • Smits M
  • Souza CF
  • Tabatabai G
  • Van Meir EG
  • Verhaak RGW
  • Watts C
  • Wesseling P
  • Woehrer A
  • Yung WKA
  • Jungk C
  • Hau AC
  • van Dyck E
  • Westerman BA
  • Yin J
  • Abiola O
  • Zeps N
  • Grimmond S
  • Buckland M
  • Khasraw M
  • Sulman EP
  • Muscat AM
  • Stead L
  • Glass Consortium.
See all publications

Contact

Simone Niclou

Ph.D.

84, rue Val Fleuri
L-1526 Luxembourg
Luxembourg
Tel. : +352 26970-273