Our research is focused on malignant brain tumours and aims to improve therapeutic options for these uncurable cancers. Patient tumors and patient derived xenograft models (PDX), which enable to translate novel treatment approaches into personalised medicine, are central to our work.

Our specific expertise and interests lie in tumour angiogenesis and invasion, tumour metabolism, and tumour cell heterogeneity and adaptability. Our research group is closely linked to the K.G. Jebsen Brain Tumour Research Center (University of Bergen, Norway), with joint research projects on glioma angiogenesis, metabolism and in vivo imaging, and has an extensive network of national and international collaborators.

Research projects

  • ADAPT: Adaptive capacities of glioblastoma: is there a role for cancer stem cells?
  • METABO: Aberrant tumour metabolism in gliomas.
  • INVGBM: Targeting glioma cell invasion.
  • CREG: Chemoresistance related RNAs in glioblastoma.
  • ANIMIX: Establishment of a national in vivo imaging platform.
  • GLIOTRAIN: Exploiting GLIOblastoma intractability to address European research TRAINing needs in translational brain tumour research, cancer systems medicine and integrative multi-omics (GLIOTRAIN Newsletters)

Featured Publications

A DNA repair and cell-cycle gene expression signature in primary and recurrent glioblastoma: prognostic value and clinical implications.

  • NORLUX-DNA repair and chemoresistance
  • Bioinformatics and Modelling
  • NORLUX-Glioma Biology
March 15, 2019
2019 Mar. Cancer Res.79(6):1226-1238. Epub 2019 Jan 23.
  • Gobin M
  • Nazarov PV
  • Warta R
  • Timmer M
  • Reifenberger G
  • Felsberg J
  • Vallar L
  • Chalmers AJ
  • Herold-Mende CC
  • Goldbrunner R
  • Niclou SP
  • Van Dyck E.

Hub genes in a pan-cancer co-expression network show potential for predicting drug responses.

  • Bioinformatics and Modelling
  • NORLUX-Glioma Biology
  • Discovery Proteomics
March 05, 2019
2019 Mar. F1000Res.7:1906.
  • Azuaje F
  • Kaoma T
  • Jeanty C
  • Nazarov PV
  • Muller A
  • Kim SY
  • Dittmar G
  • Golebiewska A
  • Niclou SP.
See all publications


Simone Niclou


84, rue Val Fleuri
L-1526 Luxembourg
Tel. : +352 26970-273