Chronic lymphocytic leukemia is the most prevalent leukemia affecting adults and remains an incurable disease associated with a tumor-supportive microenvironment. Circulating leukemic cells accumulate in blood and lymphoid organs where they establish physical contacts with stromal cells. This cross-talk influences their homing to specific niches and the evolution of the disease. We study the role of several components of the microenvironment promoting disease progression (exosomes, hypoxia) on the functions of various bystander cells. Our use of in vitro systems and mouse models combined with a strong expertise on microRNA allow us to investigate in both fundamental and applied research topics (signaling, biomarkers).

Research projects

  • Regulation and role of miRNA in stroma-leukemic cells interactions.
  • Role of exosomes in the cross-talk between cancer cells and their microenvironment.
  • Influence of hypoxic stress on miRNA regulatory machinery.

Featured Publications

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model.

  • Tumor Stroma Interactions
January 05, 2018
2018 Jan. Haematologica. [Epub ahead of print].
  • Wierz M
  • Pierson S
  • Chouha N
  • Desaubry L
  • Francois JH
  • Berchem G
  • Paggetti J
  • Moussay E.

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner.

  • Tumor Microenvironment
  • Tumor Stroma Interactions
  • National Cytometry Platform
October 31, 2017
2017 Oct. Proc Natl Acad Sci U S A.114(44):E9271-E9279. Epub 2017 Oct 16.
  • Mgrditchian T
  • Arakelian T
  • Paggetti J
  • Noman MZ
  • Viry E
  • Moussay E
  • Van Moer K
  • Kreis S
  • Guerin C
  • Buart S
  • Robert C
  • Borg C
  • Vielh P
  • Chouaib S
  • Berchem G
  • Janji B.
See all publications


Etienne Moussay


84, rue Val Fleuri
L-1526 Luxembourg
Tel. : +352 26970-232